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DOI | 10.1126/science.aao4096 |
Phosphoethanolamine cellulose: A naturally produced chemically modified cellulose | |
Thongsomboon, Wiriya1; Serra, Diego O.2; Possling, Alexandra2; Hadjineophytou, Chris2,3,4; Hengge, Regine2; Cegelski, Lynette1 | |
2018-01-19 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6373页码:334-338 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Germany; Sweden; Norway |
英文摘要 | Cellulose is a major contributor to the chemical and mechanical properties of plants and assumes structural roles in bacterial communities termed biofilms. We find that Escherichia coli produces chemically modified cellulose that is required for extracellular matrix assembly and biofilm architecture. Solid-state nuclear magnetic resonance spectroscopy of the intact and insoluble material elucidates the zwitterionic phosphoethanolamine modification that had evaded detection by conventional methods. Installation of the phosphoethanolamine group requires BcsG, a proposed phosphoethanolamine transferase, with biofilm-promoting cyclic diguanylate monophosphate input through a BcsE-BcsF-BcsG transmembrane signaling pathway. The bcsEFG operon is present in many bacteria, including Salmonella species, that also produce the modified cellulose. The discovery of phosphoethanolamine cellulose and the genetic and molecular basis for its production offers opportunities to modulate its production in bacteria and inspires efforts to biosynthetically engineer alternatively modified cellulosic materials. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000423236700040 |
WOS关键词 | ESCHERICHIA-COLI ; CURLI ; IDENTIFICATION ; TYPHIMURIUM ; ACTIVATION ; RESISTANCE ; PROTEINS ; SYNTHASE ; SYSTEM ; MATRIX |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197808 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Dept Chem, Stanford, CA 94305 USA; 2.Humboldt Univ, Inst Biol, Microbiol, D-10115 Berlin, Germany; 3.Univ Gothenburg, Dept Chem & Mol Biol, S-41296 Gothenburg, Sweden; 4.Univ Oslo, Dept Biosci, N-0371 Oslo, Norway |
推荐引用方式 GB/T 7714 | Thongsomboon, Wiriya,Serra, Diego O.,Possling, Alexandra,et al. Phosphoethanolamine cellulose: A naturally produced chemically modified cellulose[J]. SCIENCE,2018,359(6373):334-338. |
APA | Thongsomboon, Wiriya,Serra, Diego O.,Possling, Alexandra,Hadjineophytou, Chris,Hengge, Regine,&Cegelski, Lynette.(2018).Phosphoethanolamine cellulose: A naturally produced chemically modified cellulose.SCIENCE,359(6373),334-338. |
MLA | Thongsomboon, Wiriya,et al."Phosphoethanolamine cellulose: A naturally produced chemically modified cellulose".SCIENCE 359.6373(2018):334-338. |
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