The nature of nurture: Effects of parental genotypes

doi:10.1126/science.aan6877

GSTDTAP > 地球科学

DOI	10.1126/science.aan6877
	The nature of nurture: Effects of parental genotypes
	Kong, Augustine 1,2,3; Thorleifsson, Gudmar 1; Frigge, Michael L.1; Vilhjalmsson, Bjarni J.4,5; Young, Alexander I.1,2,6; Thorgeirsson, Thorgeir E.1; Benonisdottir, Stefania 1; Oddsson, Asmundur 1; Halldorsson, Bjarni V.1; Masson, Gisli 1; Gudbjartsson, Daniel F.1,3; Helgason, Agnar 1,7; Bjornsdottir, Gyda 1; Thorsteinsdottir, Unnur 1,8; Stefansson, Kari 1,8
	2018-01-26
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2018
卷号	359 期号:6374 页码:424-428
文章类型	Article
语种	英语
国家	Iceland; England; Denmark; USA
英文摘要	Sequence variants in the parental genomes that are not transmitted to a child (the proband) are often ignored in genetic studies. Here we show that nontransmitted alleles can affect a child through their impacts on the parents and other relatives, a phenomenon we call "genetic nurture." Using results from a meta-analysis of educational attainment, we find that the polygenic score computed for the nontransmitted alleles of 21,637 probands with at least one parent genotyped has an estimated effect on the educational attainment of the proband that is 29.9% (P = 1.6 x 10(-14)) of that of the transmitted polygenic score. Genetic nurturing effects of this polygenic score extend to other traits. Paternal and maternal polygenic scores have similar effects on educational attainment, but mothers contribute more than fathers to nutrition-and heath-related traits.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000423283200039
WOS关键词	GENOME-WIDE ASSOCIATION ; ADULT HUMAN HEIGHT ; SEQUENCE VARIANTS ; LINKAGE DISEQUILIBRIUM ; EDUCATIONAL-ATTAINMENT ; TRAITS ; HERITABILITY ; DISEASE ; LOCI ; ACHIEVEMENT
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/197853
专题	地球科学资源环境科学气候变化
作者单位	1.deCODE Genet Amgen, IS-101 Reykjavik, Iceland; 2.Univ Oxford, Li Ka Shing Ctr Hlth Informat & Discovery, Big Data Inst, Oxford OX3 7LF, England; 3.Univ Iceland, Sch Engn & Nat Sci, IS-101 Reykjavik, Iceland; 4.Aarhus Univ, Bioinformat Res Ctr, DK-8000 Aarhus, Denmark; 5.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA; 6.Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England; 7.Univ Iceland, Dept Anthropol, IS-101 Reykjavik, Iceland; 8.Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland
推荐引用方式 GB/T 7714	Kong, Augustine,Thorleifsson, Gudmar,Frigge, Michael L.,et al. The nature of nurture: Effects of parental genotypes[J]. SCIENCE,2018,359(6374):424-428.
APA	Kong, Augustine.,Thorleifsson, Gudmar.,Frigge, Michael L..,Vilhjalmsson, Bjarni J..,Young, Alexander I..,...&Stefansson, Kari.(2018).The nature of nurture: Effects of parental genotypes.SCIENCE,359(6374),424-428.
MLA	Kong, Augustine,et al."The nature of nurture: Effects of parental genotypes".SCIENCE 359.6374(2018):424-428.