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DOI | 10.1126/science.aan6398 |
Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks | |
Hughes, Michael P.1,2; Sawaya, Michael R.1,2; Boyer, David R.1,2; Goldschmidt, Lukasz1,2; Rodriguez, Jose A.3; Cascio, Duilio1,2; Chong, Lisa1,2; Gonen, Tamir4,5; Eisenberg, David S.1,2 | |
2018-02-09 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6376页码:698-701 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Subcellular membraneless assemblies are a reinvigorated area of study in biology, with spirited scientific discussions on the forces between the low-complexity protein domains within these assemblies. To illuminate these forces, we determined the atomic structures of five segments from protein low-complexity domains associated with membraneless assemblies. Their common structural feature is the stacking of segments into kinked beta sheets that pair into protofilaments. Unlike steric zippers of amyloid fibrils, the kinked sheets interact weakly through polar atoms and aromatic side chains. By computationally threading the human proteome on our kinked structures, we identified hundreds of low-complexity segments potentially capable of forming such interactions. These segments are found in proteins as diverse as RNA binders, nuclear pore proteins, and keratins, which are known to form networks and localize to membraneless assemblies. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000425117700043 |
WOS关键词 | RNA-BINDING PROTEINS ; AMYLOID-LIKE FIBRILS ; PRION-LIKE DOMAINS ; PHASE-SEPARATION ; LIQUID DROPLETS ; BENZENE DIMER ; SEQUENCES ; HYDROGELS ; DISEASE ; TRANSITION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197952 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.UCLA, HHMI, UCLA Dept Energy DOE Inst Genom & Prote, Dept Biol Chem, Los Angeles, CA 90095 USA; 2.UCLA, HHMI, UCLA Dept Energy DOE Inst Genom & Prote, Dept Chem & Biochem, Los Angeles, CA 90095 USA; 3.UCLA, UCLA DOE Inst Genom & Prote, Dept Chem & Biochem, Los Angeles, CA 90095 USA; 4.UCLA, HHMI, Los Angeles, CA 90095 USA; 5.UCLA, Dept Physiol, Los Angeles, CA 90095 USA |
推荐引用方式 GB/T 7714 | Hughes, Michael P.,Sawaya, Michael R.,Boyer, David R.,et al. Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks[J]. SCIENCE,2018,359(6376):698-701. |
APA | Hughes, Michael P..,Sawaya, Michael R..,Boyer, David R..,Goldschmidt, Lukasz.,Rodriguez, Jose A..,...&Eisenberg, David S..(2018).Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.SCIENCE,359(6376),698-701. |
MLA | Hughes, Michael P.,et al."Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks".SCIENCE 359.6376(2018):698-701. |
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