GSTDTAP  > 地球科学
DOI10.1126/science.aan6398
Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks
Hughes, Michael P.1,2; Sawaya, Michael R.1,2; Boyer, David R.1,2; Goldschmidt, Lukasz1,2; Rodriguez, Jose A.3; Cascio, Duilio1,2; Chong, Lisa1,2; Gonen, Tamir4,5; Eisenberg, David S.1,2
2018-02-09
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2018
卷号359期号:6376页码:698-701
文章类型Article
语种英语
国家USA
英文摘要

Subcellular membraneless assemblies are a reinvigorated area of study in biology, with spirited scientific discussions on the forces between the low-complexity protein domains within these assemblies. To illuminate these forces, we determined the atomic structures of five segments from protein low-complexity domains associated with membraneless assemblies. Their common structural feature is the stacking of segments into kinked beta sheets that pair into protofilaments. Unlike steric zippers of amyloid fibrils, the kinked sheets interact weakly through polar atoms and aromatic side chains. By computationally threading the human proteome on our kinked structures, we identified hundreds of low-complexity segments potentially capable of forming such interactions. These segments are found in proteins as diverse as RNA binders, nuclear pore proteins, and keratins, which are known to form networks and localize to membraneless assemblies.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000425117700043
WOS关键词RNA-BINDING PROTEINS ; AMYLOID-LIKE FIBRILS ; PRION-LIKE DOMAINS ; PHASE-SEPARATION ; LIQUID DROPLETS ; BENZENE DIMER ; SEQUENCES ; HYDROGELS ; DISEASE ; TRANSITION
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/197952
专题地球科学
资源环境科学
气候变化
作者单位1.UCLA, HHMI, UCLA Dept Energy DOE Inst Genom & Prote, Dept Biol Chem, Los Angeles, CA 90095 USA;
2.UCLA, HHMI, UCLA Dept Energy DOE Inst Genom & Prote, Dept Chem & Biochem, Los Angeles, CA 90095 USA;
3.UCLA, UCLA DOE Inst Genom & Prote, Dept Chem & Biochem, Los Angeles, CA 90095 USA;
4.UCLA, HHMI, Los Angeles, CA 90095 USA;
5.UCLA, Dept Physiol, Los Angeles, CA 90095 USA
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Hughes, Michael P.,Sawaya, Michael R.,Boyer, David R.,et al. Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks[J]. SCIENCE,2018,359(6376):698-701.
APA Hughes, Michael P..,Sawaya, Michael R..,Boyer, David R..,Goldschmidt, Lukasz.,Rodriguez, Jose A..,...&Eisenberg, David S..(2018).Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.SCIENCE,359(6376),698-701.
MLA Hughes, Michael P.,et al."Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks".SCIENCE 359.6376(2018):698-701.
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