GSTDTAP  > 地球科学
DOI10.1126/science.aao4798
Enantioselective C(sp(3))-H bond activation by chiral transition metal catalysts
Saint-Denis, Tyler G.; Zhu, Ru-Yi; Chen, Gang; Wu, Qing-Feng; Yu, Jin-Quan
2018-02-16
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2018
卷号359期号:6377页码:759-+
文章类型Review
语种英语
国家USA
英文摘要

Organic molecules are rich in carbon-hydrogen bonds; consequently, the transformation of C-H bonds to new functionalities (such as C-C, C-N, and C-O bonds) has garnered much attention by the synthetic chemistry community. The utility of C-H activation in organic synthesis, however, cannot be fully realized until chemists achieve stereocontrol in the modification of C-H bonds. This Review highlights recent efforts to enantioselectively functionalize C(sp(3))-H bonds via transition metal catalysis, with an emphasis on key principles for both the development of chiral ligand scaffolds that can accelerate metalation of C(sp(3))-H bonds and stereomodels for asymmetric metalation of prochiral C-H bonds by these catalysts.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000425116200036
WOS关键词C-H BONDS ; KINETIC RESOLUTION ; ASYMMETRIC CATALYSIS ; AMINO-ACIDS ; PD-II ; LIGAND ; FUNCTIONALIZATION ; ARYLATION ; IODINATION ; SILYLATION
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/197991
专题地球科学
资源环境科学
气候变化
作者单位Scripps Res Inst, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA
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Saint-Denis, Tyler G.,Zhu, Ru-Yi,Chen, Gang,et al. Enantioselective C(sp(3))-H bond activation by chiral transition metal catalysts[J]. SCIENCE,2018,359(6377):759-+.
APA Saint-Denis, Tyler G.,Zhu, Ru-Yi,Chen, Gang,Wu, Qing-Feng,&Yu, Jin-Quan.(2018).Enantioselective C(sp(3))-H bond activation by chiral transition metal catalysts.SCIENCE,359(6377),759-+.
MLA Saint-Denis, Tyler G.,et al."Enantioselective C(sp(3))-H bond activation by chiral transition metal catalysts".SCIENCE 359.6377(2018):759-+.
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