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DOI | 10.1126/science.aao4798 |
Enantioselective C(sp(3))-H bond activation by chiral transition metal catalysts | |
Saint-Denis, Tyler G.; Zhu, Ru-Yi; Chen, Gang; Wu, Qing-Feng; Yu, Jin-Quan | |
2018-02-16 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6377页码:759-+ |
文章类型 | Review |
语种 | 英语 |
国家 | USA |
英文摘要 | Organic molecules are rich in carbon-hydrogen bonds; consequently, the transformation of C-H bonds to new functionalities (such as C-C, C-N, and C-O bonds) has garnered much attention by the synthetic chemistry community. The utility of C-H activation in organic synthesis, however, cannot be fully realized until chemists achieve stereocontrol in the modification of C-H bonds. This Review highlights recent efforts to enantioselectively functionalize C(sp(3))-H bonds via transition metal catalysis, with an emphasis on key principles for both the development of chiral ligand scaffolds that can accelerate metalation of C(sp(3))-H bonds and stereomodels for asymmetric metalation of prochiral C-H bonds by these catalysts. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000425116200036 |
WOS关键词 | C-H BONDS ; KINETIC RESOLUTION ; ASYMMETRIC CATALYSIS ; AMINO-ACIDS ; PD-II ; LIGAND ; FUNCTIONALIZATION ; ARYLATION ; IODINATION ; SILYLATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197991 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | Scripps Res Inst, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA |
推荐引用方式 GB/T 7714 | Saint-Denis, Tyler G.,Zhu, Ru-Yi,Chen, Gang,et al. Enantioselective C(sp(3))-H bond activation by chiral transition metal catalysts[J]. SCIENCE,2018,359(6377):759-+. |
APA | Saint-Denis, Tyler G.,Zhu, Ru-Yi,Chen, Gang,Wu, Qing-Feng,&Yu, Jin-Quan.(2018).Enantioselective C(sp(3))-H bond activation by chiral transition metal catalysts.SCIENCE,359(6377),759-+. |
MLA | Saint-Denis, Tyler G.,et al."Enantioselective C(sp(3))-H bond activation by chiral transition metal catalysts".SCIENCE 359.6377(2018):759-+. |
条目包含的文件 | 条目无相关文件。 |
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