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DOI | 10.1126/science.aao6058 |
Evidence for a neural law of effect | |
Athalye, Vivek R.1,2; Santos, Fernando J.1; Carmena, Jose M.2,3,4,5; Costa, Rui M.1,6,7 | |
2018-03-02 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6379页码:1024-1029 |
文章类型 | Article |
语种 | 英语 |
国家 | Portugal; USA |
英文摘要 | Thorndike's law of effect states that actions that lead to reinforcements tend to be repeated more often. Accordingly, neural activity patterns leading to reinforcement are also reentered more frequently. Reinforcement relies on dopaminergic activity in the ventral tegmental area (VTA), and animals shape their behavior to receive dopaminergic stimulation. Seeking evidence for a neural law of effect, we found that mice learn to reenter more frequently motor cortical activity patterns that trigger optogenetic VTA self-stimulation. Learning was accompanied by gradual shaping of these patterns, with participating neurons progressively increasing and aligning their covariance to that of the target pattern. Motor cortex patterns that lead to phasic dopaminergic VTA activity are progressively reinforced and shaped, suggesting a mechanism by which animals select and shape actions to reliably achieve reinforcement. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000426366200040 |
WOS关键词 | DENDRITIC SPINES ; CORTICOSTRIATAL PLASTICITY ; MOTOR CORTEX ; CLOSED-LOOP ; REINFORCEMENT ; NEURONS ; REWARD ; BRAIN ; STIMULATION ; RECOMBINASE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198092 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Champalimaud Ctr Unknown, Champalimaud Neurosci Programme, P-1400038 Lisbon, Portugal; 2.Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA; 3.Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA; 4.Univ Calif Berkeley, Joint Grad Grp Bioengn, Berkeley, CA 94720 USA; 5.Univ Calif San Francisco, Berkeley, CA 94720 USA; 6.Columbia Univ, Zuckerman Mind Brain Behav Inst, Dept Neurosci, New York, NY 10032 USA; 7.Columbia Univ, Zuckerman Mind Brain Behav Inst, Dept Neurol, New York, NY 10032 USA |
推荐引用方式 GB/T 7714 | Athalye, Vivek R.,Santos, Fernando J.,Carmena, Jose M.,et al. Evidence for a neural law of effect[J]. SCIENCE,2018,359(6379):1024-1029. |
APA | Athalye, Vivek R.,Santos, Fernando J.,Carmena, Jose M.,&Costa, Rui M..(2018).Evidence for a neural law of effect.SCIENCE,359(6379),1024-1029. |
MLA | Athalye, Vivek R.,et al."Evidence for a neural law of effect".SCIENCE 359.6379(2018):1024-1029. |
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