GSTDTAP  > 地球科学
DOI10.1126/science.aao6058
Evidence for a neural law of effect
Athalye, Vivek R.1,2; Santos, Fernando J.1; Carmena, Jose M.2,3,4,5; Costa, Rui M.1,6,7
2018-03-02
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2018
卷号359期号:6379页码:1024-1029
文章类型Article
语种英语
国家Portugal; USA
英文摘要

Thorndike's law of effect states that actions that lead to reinforcements tend to be repeated more often. Accordingly, neural activity patterns leading to reinforcement are also reentered more frequently. Reinforcement relies on dopaminergic activity in the ventral tegmental area (VTA), and animals shape their behavior to receive dopaminergic stimulation. Seeking evidence for a neural law of effect, we found that mice learn to reenter more frequently motor cortical activity patterns that trigger optogenetic VTA self-stimulation. Learning was accompanied by gradual shaping of these patterns, with participating neurons progressively increasing and aligning their covariance to that of the target pattern. Motor cortex patterns that lead to phasic dopaminergic VTA activity are progressively reinforced and shaped, suggesting a mechanism by which animals select and shape actions to reliably achieve reinforcement.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000426366200040
WOS关键词DENDRITIC SPINES ; CORTICOSTRIATAL PLASTICITY ; MOTOR CORTEX ; CLOSED-LOOP ; REINFORCEMENT ; NEURONS ; REWARD ; BRAIN ; STIMULATION ; RECOMBINASE
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/198092
专题地球科学
资源环境科学
气候变化
作者单位1.Champalimaud Ctr Unknown, Champalimaud Neurosci Programme, P-1400038 Lisbon, Portugal;
2.Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA;
3.Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA;
4.Univ Calif Berkeley, Joint Grad Grp Bioengn, Berkeley, CA 94720 USA;
5.Univ Calif San Francisco, Berkeley, CA 94720 USA;
6.Columbia Univ, Zuckerman Mind Brain Behav Inst, Dept Neurosci, New York, NY 10032 USA;
7.Columbia Univ, Zuckerman Mind Brain Behav Inst, Dept Neurol, New York, NY 10032 USA
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Athalye, Vivek R.,Santos, Fernando J.,Carmena, Jose M.,et al. Evidence for a neural law of effect[J]. SCIENCE,2018,359(6379):1024-1029.
APA Athalye, Vivek R.,Santos, Fernando J.,Carmena, Jose M.,&Costa, Rui M..(2018).Evidence for a neural law of effect.SCIENCE,359(6379),1024-1029.
MLA Athalye, Vivek R.,et al."Evidence for a neural law of effect".SCIENCE 359.6379(2018):1024-1029.
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