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DOI | 10.1126/science.aao5774 |
Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes | |
Zhao, Liping1,2,3,4; Zhang, Feng1,2; Ding, Xiaoying5; Wu, Guojun1,2; Lam, Yan Y.3,4; Wang, Xuejiao5; Fu, Huaqing1,2; Xue, Xinhe1,2; Lu, Chunhua6; Ma, Jilin6; Yu, Lihua6; Xu, Chengmei6; Ren, Zhongying6; Xu, Ying7; Xu, Songmei7; Shen, Hongli7; Zhu, Xiuli7; Shi, Yu8; Shen, Qingyun8; Dong, Weiping5; Liu, Rui1,2; Ling, Yunxia5; Zeng, Yue9; Wang, Xingpeng9; Zhang, Qianpeng1,2; Wang, Jing1,2; Wang, Linghua1,2; Wu, Yanqiu1,2; Zeng, Benhua10; Wei, Hong10; Zhang, Menghui1,2; Peng, Yongde5; Zhang, Chenhong1,2 | |
2018-03-09 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6380页码:1151-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 diabetes mellitus (T2DM). We conducted a randomized clinical study of specifically designed isoenergetic diets, together with fecal shotgun metagenomics, to show that a select group of SCFA-producing strains was promoted by dietary fibers and that most other potential producers were either diminished or unchanged in patients with T2DM. When the fiber-promoted SCFA producers were present in greater diversity and abundance, participants had better improvement in hemoglobin A1c levels, partly via increased glucagon-like peptide-1 production. Promotion of these positive responders diminished producers of metabolically detrimental compounds such as indole and hydrogen sulfide. Targeted restoration of these SCFA producers may present a novel ecological approach for managing T2DM. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000426835900045 |
WOS关键词 | MICROBIOTA COMPOSITION ; GLUCOSE ; METAGENOME ; GHRELIN ; OBESITY ; INDEX ; ACID ; PH |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198147 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China; 2.Shanghai Jiao Tong Univ, Minist Educ, Key Lab Syst Biomed, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China; 3.Rutgers State Univ, Dept Biochem & Microbiol, Sch Environm & Biol Sci, New Brunswick, NJ 08901 USA; 4.Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, Sch Environm & Biol Sci, New Brunswick, NJ 08901 USA; 5.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Endocrinol & Metab, Sch Med, Shanghai 200080, Peoples R China; 6.Sijing Community Hlth Serv Ctr Songjiang Dist, Shanghai 201601, Peoples R China; 7.Sijing Hosp Songjiang Dist, Shanghai 201601, Peoples R China; 8.Qidong Peoples Hosp, Dept Endocrinol & Metab, Nantong 226200, Jiangsu, Peoples R China; 9.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Gastroenterol, Sch Med, Shanghai 200080, Peoples R China; 10.Army Med Univ, Dept Lab Anim Sci, Coll Basic Med Sci, Chongqing 400038, Peoples R China |
推荐引用方式 GB/T 7714 | Zhao, Liping,Zhang, Feng,Ding, Xiaoying,et al. Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes[J]. SCIENCE,2018,359(6380):1151-+. |
APA | Zhao, Liping.,Zhang, Feng.,Ding, Xiaoying.,Wu, Guojun.,Lam, Yan Y..,...&Zhang, Chenhong.(2018).Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes.SCIENCE,359(6380),1151-+. |
MLA | Zhao, Liping,et al."Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes".SCIENCE 359.6380(2018):1151-+. |
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