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DOI | 10.1126/science.aam6603 |
Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells | |
Nabhan, Ahmad N.1,2; Brownfield, Douglas G.1,2; Harbury, Pehr B.1; Krasnow, Mark A.1,2; Desai, Tushar J.3,4 | |
2018-03-09 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6380页码:1118-1123 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Alveoli, the lung's respiratory units, are tiny sacs where oxygen enters the bloodstream. They are lined by flat alveolar type 1 (AT1) cells, which mediate gas exchange, and AT2 cells, which secrete surfactant. Rare AT2s also function as alveolar stem cells. We show that AT2 lung stem cells display active Wnt signaling, and many of them are near single, Wnt-expressing fibroblasts. Blocking Wnt secretion depletes these stem cells. Daughter cells leaving the Wnt niche transdifferentiate into AT1s: Maintaining Wnt signaling prevents transdifferentiation, whereas abrogating Wnt signaling promotes it. Injury induces AT2 autocrine Wnts, recruiting "bulk" AT2s as progenitors. Thus, individual AT2 stem cells reside in single-cell fibroblast niches providing juxtacrine Wnts that maintain them, whereas injury induces autocrine Wnts that transiently expand the progenitor pool. This simple niche maintains the gas exchange surface and is coopted in cancer. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000426835900037 |
WOS关键词 | EPITHELIAL SELF-RENEWAL ; BETA-CATENIN ; LUNG ; PROTEINS ; PROGRESSION ; PROGENITOR |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198156 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Dept Biochem, Sch Med, Stanford, CA 94305 USA; 2.Stanford Univ, Howard Hughes Med Inst, Sch Med, Stanford, CA 94305 USA; 3.Stanford Univ, Sch Med, Div Pulm & Crit Care, Dept Internal Med, Stanford, CA 94305 USA; 4.Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Nabhan, Ahmad N.,Brownfield, Douglas G.,Harbury, Pehr B.,et al. Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells[J]. SCIENCE,2018,359(6380):1118-1123. |
APA | Nabhan, Ahmad N.,Brownfield, Douglas G.,Harbury, Pehr B.,Krasnow, Mark A.,&Desai, Tushar J..(2018).Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells.SCIENCE,359(6380),1118-1123. |
MLA | Nabhan, Ahmad N.,et al."Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells".SCIENCE 359.6380(2018):1118-1123. |
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