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DOI | 10.1126/science.aan6042 |
GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing | |
Filarsky, Michael1,2; Fraschka, Sabine A.3; Niederwieser, Igor1,2; Brancucci, Nicolas M. B.1,2; Carrington, Eilidh1,2; Carrio, Elvira1,2; Moes, Suzette4; Jenoe, Paul4; Bartfai, Richard3; Voss, Till S.1,2 | |
2018-03-16 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6381页码:1259-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland; Netherlands |
英文摘要 | Malaria is caused by Plasmodium parasites that proliferate in the bloodstream. During each replication cycle, some parasites differentiate into gametocytes, the only forms able to infect the mosquito vector and transmit malaria. Sexual commitment is triggered by activation of AP2-G, the master transcriptional regulator of gametocytogenesis. Heterochromatin protein 1 (HP1)-dependent silencing of ap2-g prevents sexual conversion in proliferating parasites. In this study, we identified Plasmodium falciparum gametocyte development 1 (GDV1) as an upstream activator of sexual commitment. We found that GDV1 targeted heterochromatin and triggered HP1 eviction, thus derepressing ap2-g. Expression of GDV1 was responsive to environmental triggers of sexual conversion and controlled via a gdv1 antisense RNA. Hence, GDV1 appears to act as an effector protein that induces sexual differentiation by antagonizing HP1-dependent gene silencing. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000427504900041 |
WOS关键词 | PLASMODIUM-FALCIPARUM ; ANTISENSE TRANSCRIPTION ; STAGE ; GAMETOCYTOGENESIS ; DIFFERENTIATION ; GAMETOGENESIS ; GAMETOCYTES ; EXPRESSION ; CHROMATIN ; PROTEINS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198202 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Swiss Trop & Publ Hlth Inst, CH-4051 Basel, Switzerland; 2.Univ Basel, CH-4003 Basel, Switzerland; 3.Radboud Univ Nijmegen, Dept Mol Biol, NL-6525 GA Nijmegen, Netherlands; 4.Univ Basel, Biozentrum, CH-4056 Basel, Switzerland |
推荐引用方式 GB/T 7714 | Filarsky, Michael,Fraschka, Sabine A.,Niederwieser, Igor,et al. GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing[J]. SCIENCE,2018,359(6381):1259-+. |
APA | Filarsky, Michael.,Fraschka, Sabine A..,Niederwieser, Igor.,Brancucci, Nicolas M. B..,Carrington, Eilidh.,...&Voss, Till S..(2018).GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing.SCIENCE,359(6381),1259-+. |
MLA | Filarsky, Michael,et al."GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing".SCIENCE 359.6381(2018):1259-+. |
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