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DOI | 10.1126/science.aal3662 |
Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice | |
Brown, M.1,2; Assen, F. P.2; Leithner, A.2; Abe, J.3; Schachner, H.1; Asfour, G.1; Bago-Horvath, Z.1; Stein, J. V.3; Uhrin, P.4; Sixt, M.2; Kerjaschki, D.1 | |
2018-03-23 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6382页码:1408-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Austria; Switzerland |
英文摘要 | During metastasis, malignant cells escape the primary tumor, intravasate lymphatic vessels, and reach draining sentinel lymph nodes before they colonize distant organs via the blood circulation. Although lymph node metastasis in cancer patients correlates with poor prognosis, evidence is lacking as to whether and how tumor cells enter the bloodstream via lymph nodes. To investigate this question, we delivered carcinoma cells into the lymph nodes of mice by microinfusing the cells into afferent lymphatic vessels. We found that tumor cells rapidly infiltrated the lymph node parenchyma, invaded blood vessels, and seeded lung metastases without involvement of the thoracic duct. These results suggest that the lymph node blood vessels can serve as an exit route for systemic dissemination of cancer cells in experimental mouse models. Whether this form of tumor cell spreading occurs in cancer patients remains to be determined. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000428043600047 |
WOS关键词 | BREAST-CANCER ; PREMENOPAUSAL WOMEN ; DISTANT METASTASES ; LYMPHANGIOGENESIS ; RADIOTHERAPY ; VASCULATURE ; IRRADIATION ; INVOLVEMENT ; INVASION ; MAMMARY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198251 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Med Univ Vienna, Clin Inst Pathol, A-1090 Vienna, Austria; 2.IST Austria, A-3400 Klosterneuburg, Austria; 3.Univ Bern, Theodor Kocher Inst, CH-3012 Bern, Switzerland; 4.Med Univ Vienna, Inst Vasc Biol, A-1090 Vienna, Austria |
推荐引用方式 GB/T 7714 | Brown, M.,Assen, F. P.,Leithner, A.,et al. Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice[J]. SCIENCE,2018,359(6382):1408-+. |
APA | Brown, M..,Assen, F. P..,Leithner, A..,Abe, J..,Schachner, H..,...&Kerjaschki, D..(2018).Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice.SCIENCE,359(6382),1408-+. |
MLA | Brown, M.,et al."Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice".SCIENCE 359.6382(2018):1408-+. |
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