Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice

doi:10.1126/science.aal3622

GSTDTAP > 地球科学

DOI	10.1126/science.aal3622
	Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice
	Pereira, Ethel R.; Kedrin, Dmitriy 1,2; Seano, Giorgio ; Gautier, Olivia 3; Meijer, Eelco F. J.; Jones, Dennis ; Chin, Shan-Min ; Kitahara, Shuji ; Bouta, Echoe M.; Chang, Jonathan 2,4,5; Beech, Elizabeth ; Jeong, Han-Sin 6,7; Carroll, Michael C.2,5,8; Taghian, Alphonse G.2,9; Padera, Timothy P.
	2018-03-23
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2018
卷号	359 期号:6382 页码:1403-1407
文章类型	Article
语种	英语
国家	USA; South Korea
英文摘要	Lymph node metastases in cancer patients are associated with tumor aggressiveness, poorer prognoses, and the recommendation for systemic therapy. Whether cancer cells in lymph nodes can seed distant metastases has been a subject of considerable debate. We studied mice implanted with cancer cells (mammary carcinoma, squamous cell carcinoma, or melanoma) expressing the photoconvertible protein Dendra2. This technology allowed us to selectively photoconvert metastatic cells in the lymph node and trace their fate. We found that a fraction of these cells invaded lymph node blood vessels, entered the blood circulation, and colonized the lung. Thus, in mouse models, lymph node metastases can be a source of cancer cells for distant metastases. Whether this mode of dissemination occurs in cancer patients remains to be determined.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000428043600046
WOS关键词	BREAST-CANCER ; SENTINEL-NODE ; PREMENOPAUSAL WOMEN ; AXILLARY DISSECTION ; RADIOTHERAPY ; IRRADIATION ; CARCINOMA ; SURVIVAL ; MAMMARY ; SURGERY
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/198252
专题	地球科学资源环境科学气候变化
作者单位	1.MGH, Div Gastroenterol, Boston, MA 02114 USA; 2.HMS, Boston, MA 02114 USA; 3.MIT, Dept Biol Engn, Cambridge, MA 02142 USA; 4.HMS, Div Med Sci, Grad Program Immunol, Boston, MA 02115 USA; 5.Childrens Hosp, Program Cellular & Mol Med, 300 Longwood Ave, Boston, MA 02115 USA; 6.Sungkyunkwan Univ, Dept Otorhinolaryngol, Samsung Med Ctr, Sch Med, Seoul, South Korea; 7.Sungkyunkwan Univ, Head & Neck Canc Ctr, Samsung Med Ctr, Sch Med, Seoul, South Korea; 8.Childrens Hosp, Dept Pediat, Boston, MA 02115 USA; 9.MGH, Dept Radiat Oncol, Boston, MA 02114 USA
推荐引用方式 GB/T 7714	Pereira, Ethel R.,Kedrin, Dmitriy,Seano, Giorgio,et al. Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice[J]. SCIENCE,2018,359(6382):1403-1407.
APA	Pereira, Ethel R..,Kedrin, Dmitriy.,Seano, Giorgio.,Gautier, Olivia.,Meijer, Eelco F. J..,...&Padera, Timothy P..(2018).Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice.SCIENCE,359(6382),1403-1407.
MLA	Pereira, Ethel R.,et al."Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice".SCIENCE 359.6382(2018):1403-1407.