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DOI | 10.1126/science.aap8861 |
Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance | |
Decker, Matthew; Leslie, Juliana; Liu, Qingxue; Ding, Lei1 | |
2018-04-06 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6384页码:106-110 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Hematopoietic stem cell (HSC) maintenance depends on extrinsic cues. Currently, only local signals arising from the bone marrow niche have been shown to maintain HSCs. However, it is not known whether systemic factors also sustain HSCs. We assessed the physiological source of thrombopoietin (TPO), a key cytokine required for maintaining HSCs. Using Tpo(DsRed-CreER) knock-in mice, we showed that TPO is expressed by hepatocytes but not by bone marrow cells. Deletion of Tpo from hematopoietic cells, osteoblasts, or bone marrow mesenchymal stromal cells does not affect HSC number or function. However, when Tpo is deleted from hepatocytes, bone marrow HSCs are depleted. Thus, a cross-organ factor, circulating TPO made in the liver by hepatocytes, is required for bone marrow HSC maintenance. Our results demonstrate that systemic factors, in addition to the local niche, are a critical extrinsic component for HSC maintenance. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000429263100056 |
WOS关键词 | C-MPL ; PROGENITOR CELLS ; MICE LACKING ; LIVER ; MEGAKARYOCYTOPOIESIS ; DEFICIENCIES ; STIMULATION ; QUIESCENCE ; EXPRESSION ; RECEPTOR |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198344 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Columbia Univ, Med Ctr, Dept Rehabil & Regenerat Med, Columbia Stem Cell Initiat, New York, NY 10032 USA; 2.Columbia Univ, Med Ctr, Dept Microbiol & Immunol, New York, NY 10032 USA |
推荐引用方式 GB/T 7714 | Decker, Matthew,Leslie, Juliana,Liu, Qingxue,et al. Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance[J]. SCIENCE,2018,360(6384):106-110. |
APA | Decker, Matthew,Leslie, Juliana,Liu, Qingxue,&Ding, Lei.(2018).Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance.SCIENCE,360(6384),106-110. |
MLA | Decker, Matthew,et al."Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance".SCIENCE 360.6384(2018):106-110. |
条目包含的文件 | 条目无相关文件。 |
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