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DOI | 10.1126/science.aao7298 |
Structure of the herpes simplex virus 1 capsid with associated tegument protein complexes | |
Dai, Xinghong1,2; Zhou, Z. Hong1,2 | |
2018-04-06 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6384页码:47-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Herpes simplex viruses (HSVs) rely on capsid-associated tegument complex (CATC) for long-range axonal transport of their genome-containing capsids between sites of infection and neuronal cell bodies. Here we report cryo-electron microscopy structures of the HSV-1 capsid with CATC up to 3.5-angstrom resolution and atomic models of multiple conformers of capsid proteins VP5, VP19c, VP23, and VP26 and tegument proteins pUL17, pUL25, and pUL36. Crowning every capsid vertex are five copies of heteropentameric CATC, each containing a pUL17 monomer supporting the coiled-coil helix bundle of a pUL25 dimer and a pUL36 dimer, thus positioning their flexible domains for potential involvement in nuclear capsid egress and axonal capsid transport. Notwithstanding newly discovered fold conservation between triplex proteins and bacteriophage A. protein gpD and the previously recognized bacteriophage HK97 gp5-like fold in VP5, HSV-1 capsid proteins exhibit extraordinary diversity in forms of domain insertion and conformational polymorphism, not only for interactions with tegument proteins but also for encapsulation of large genomes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000429263100041 |
WOS关键词 | VERTEX-SPECIFIC COMPONENT ; PSEUDORABIES VIRUS ; NUCLEAR EGRESS ; ELECTRON-MICROSCOPY ; MUTAGENESIS REVEAL ; CYTOPLASMIC TAIL ; UL25 PROTEIN ; DNA ; TYPE-1 ; BINDING |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198346 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA; 2.Univ Calif Los Angeles, Calif Nanosyst Inst, Los Angeles, CA 90095 USA |
推荐引用方式 GB/T 7714 | Dai, Xinghong,Zhou, Z. Hong. Structure of the herpes simplex virus 1 capsid with associated tegument protein complexes[J]. SCIENCE,2018,360(6384):47-+. |
APA | Dai, Xinghong,&Zhou, Z. Hong.(2018).Structure of the herpes simplex virus 1 capsid with associated tegument protein complexes.SCIENCE,360(6384),47-+. |
MLA | Dai, Xinghong,et al."Structure of the herpes simplex virus 1 capsid with associated tegument protein complexes".SCIENCE 360.6384(2018):47-+. |
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