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DOI | 10.1126/science.aan8795 |
Cell cycle heterogeneity directs the timing of neural stem cell activation from quiescence | |
Otsuki, L.; Brand, A. H.1 | |
2018-04-06 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6384页码:99-+ |
文章类型 | Article |
语种 | 英语 |
国家 | England |
英文摘要 | Quiescent stem cells in adult tissues can be activated for homeostasis or repair. Neural stem cells (NSCs) in Drosophila are reactivated from quiescence in response to nutrition by the insulin signaling pathway. It is widely accepted that quiescent stem cells are arrested in Go. In this study, however, we demonstrate that quiescent NSCs (qNSCs) are arrested in either G(2) or G(0). G(2)-G(0) heterogeneity directs NSC behavior: G(2) qNSCs reactivate before Go qNSCs. In addition, we show that the evolutionarily conserved pseudokinase Tribbles (Trbl) induces G(2) NSCs to enter quiescence by promoting degradation of Cdc25(string) and that it subsequently maintains quiescence by inhibiting Akt activation. Insulin signaling overrides repression of Akt and silences trbl transcription, allowing NSCs to exit quiescence. Our results have implications for identifying and manipulating quiescent stem cells for regenerative purposes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000429263100054 |
WOS关键词 | DROSOPHILA-MELANOGASTER ; PROLIFERATION ; MORPHOGENESIS ; NEUROBLASTS ; TRIBBLES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
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文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198353 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Cambridge, Gurdon Inst, Tennis Court Rd, Cambridge CB2 1QN, England; 2.Univ Cambridge, Dept Physiol Dev & Neurosci, Tennis Court Rd, Cambridge CB2 1QN, England |
推荐引用方式 GB/T 7714 | Otsuki, L.,Brand, A. H.. Cell cycle heterogeneity directs the timing of neural stem cell activation from quiescence[J]. SCIENCE,2018,360(6384):99-+. |
APA | Otsuki, L.,&Brand, A. H..(2018).Cell cycle heterogeneity directs the timing of neural stem cell activation from quiescence.SCIENCE,360(6384),99-+. |
MLA | Otsuki, L.,et al."Cell cycle heterogeneity directs the timing of neural stem cell activation from quiescence".SCIENCE 360.6384(2018):99-+. |
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