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DOI | 10.1126/science.aap8179 ; 10.1126/science.aap8179 |
Self-organization and progenitor targeting generate stable patterns in planarian regeneration; Self-organization and progenitor targeting generate stable patterns in planarian regeneration | |
Atabay, Kutay Deniz1,2,3; LoCascio, Samuel A.1,2,3; de Hoog, Thom1,3; Reddien, PeterW.1,3,4 | |
2018-04-27 ; 2018-04-27 | |
发表期刊 | SCIENCE ; SCIENCE |
ISSN | 0036-8075 ; 0036-8075 |
EISSN | 1095-9203 ; 1095-9203 |
出版年 | 2018 ; 2018 |
卷号 | 360期号:6387页码:404-+ |
文章类型 | Article ; Article |
语种 | 英语 ; 英语 |
国家 | USA; USA |
英文摘要 | During animal regeneration, cells must organize into discrete and functional systems. We show that self-organization, along with patterning cues, govern progenitor behavior in planarian regeneration. Surgical paradigms allowed the manipulation of planarian eye regeneration in predictable locations and numbers, generating alternative stable neuroanatomical states for wild-type animals with multiple functional ectopic eyes. We used animals with multiple ectopic eyes and eye transplantation to demonstrate that broad progenitor specification, combined with self-organization, allows anatomy maintenance during regeneration. We propose a model for regenerative progenitors involving (i) migratory targeting cues, (ii) self-organization into existing or regenerating eyes, and (iii) a broad zone, associated with coarse progenitor specification, in which eyes can be targeted by progenitors. These three properties help explain how tissues can be organized during regeneration. ; During animal regeneration, cells must organize into discrete and functional systems. We show that self-organization, along with patterning cues, govern progenitor behavior in planarian regeneration. Surgical paradigms allowed the manipulation of planarian eye regeneration in predictable locations and numbers, generating alternative stable neuroanatomical states for wild-type animals with multiple functional ectopic eyes. We used animals with multiple ectopic eyes and eye transplantation to demonstrate that broad progenitor specification, combined with self-organization, allows anatomy maintenance during regeneration. We propose a model for regenerative progenitors involving (i) migratory targeting cues, (ii) self-organization into existing or regenerating eyes, and (iii) a broad zone, associated with coarse progenitor specification, in which eyes can be targeted by progenitors. These three properties help explain how tissues can be organized during regeneration. |
领域 | 地球科学 ; 地球科学 ; 气候变化 ; 气候变化 ; 资源环境 ; 资源环境 |
收录类别 | SCI-E ; SCI-E |
WOS记录号 | WOS:000430949600034 ; WOS:000430949600034 |
WOS关键词 | EYE REGENERATION ; EYE REGENERATION ; STEM-CELLS ; STEM-CELLS ; MAINTENANCE ; MAINTENANCE ; WOUNDS ; WOUNDS |
WOS类目 | Multidisciplinary Sciences ; Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics ; Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198512 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Whitehead Inst Biomed Res, Cambridge, MA 02142 USA; 2.MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA; 3.MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA; 4.MIT, Dept Biol, Cambridge, MA 02139 USA |
推荐引用方式 GB/T 7714 | Atabay, Kutay Deniz,LoCascio, Samuel A.,de Hoog, Thom,et al. Self-organization and progenitor targeting generate stable patterns in planarian regeneration, Self-organization and progenitor targeting generate stable patterns in planarian regeneration[J]. SCIENCE, SCIENCE,2018, 2018,360, 360(6387):404-+, 404-+. |
APA | Atabay, Kutay Deniz,LoCascio, Samuel A.,de Hoog, Thom,&Reddien, PeterW..(2018).Self-organization and progenitor targeting generate stable patterns in planarian regeneration.SCIENCE,360(6387),404-+. |
MLA | Atabay, Kutay Deniz,et al."Self-organization and progenitor targeting generate stable patterns in planarian regeneration".SCIENCE 360.6387(2018):404-+. |
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