GSTDTAP  > 地球科学
DOI10.1126/science.aar2663
NUFIP1 is a ribosome receptor for starvation-induced ribophagy
Wyant, Gregory A.1,2,3,4,5; Abu-Remaileh, Monther1,2,3,4,5; Frenkel, Evgeni M.1,2,3,4,5; Laqtom, Nouf N.1,2,3,4,5; Dharamdasani, Vimisha1,2,3,4,5; Lewis, Caroline A.1,2; Chan, Sze Ham1,2; Heinze, Ivonne6; Ori, Alessandro6; Sabatini, David M.1,2,3,4,5
2018-05-18
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2018
卷号360期号:6390页码:751-+
文章类型Article
语种英语
国家USA; Germany
英文摘要

The lysosome degrades and recycles macromolecules, signals to the master growth regulator mTORC1 [mechanistic target of rapamycin (mTOR) complex 1], and is associated with human disease. We performed quantitative proteomic analyses of rapidly isolated lysosomes and found that nutrient levels and mTOR dynamically modulate the lysosomal proteome. Upon mTORC1 inhibition, NUFIP1 (nuclear fragile Xmental retardation-interacting protein 1) redistributes from the nucleus to autophagosomes and lysosomes. Upon these conditions, NUFIP1 interacts with ribosomes and delivers them to autophagosomes by directly binding to microtubule-associated proteins 1A/1B light chain 3B (LC3B). The starvation-induced degradation of ribosomes via autophagy (ribophagy) depends on the capacity of NUFIP1 to bind LC3B and promotes cell survival. We propose that NUFIP1 is a receptor for the selective autophagy of ribosomes.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000432473500040
WOS关键词HEREDITARY SPASTIC PARAPLEGIA ; AUTOPHAGY RECEPTOR ; SELECTIVE AUTOPHAGY ; RAG GTPASES ; LYSOSOMES ; PROTEINS ; CELLS ; YEAST ; MTORC1 ; DEGRADATION
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/198696
专题地球科学
资源环境科学
气候变化
作者单位1.MIT, Whitehead Inst Biomed Res, Cambridge, MA 02142 USA;
2.MIT, Dept Biol, Cambridge, MA 02142 USA;
3.MIT, Howard Hughes Med Inst, Dept Biol, Cambridge, MA 02139 USA;
4.MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02142 USA;
5.Broad Inst Harvard & MIT, Cambridge, MA 02142 USA;
6.Leibniz Inst Aging, Fritz Lipmann Inst, D-07745 Jena, Germany
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GB/T 7714
Wyant, Gregory A.,Abu-Remaileh, Monther,Frenkel, Evgeni M.,et al. NUFIP1 is a ribosome receptor for starvation-induced ribophagy[J]. SCIENCE,2018,360(6390):751-+.
APA Wyant, Gregory A..,Abu-Remaileh, Monther.,Frenkel, Evgeni M..,Laqtom, Nouf N..,Dharamdasani, Vimisha.,...&Sabatini, David M..(2018).NUFIP1 is a ribosome receptor for starvation-induced ribophagy.SCIENCE,360(6390),751-+.
MLA Wyant, Gregory A.,et al."NUFIP1 is a ribosome receptor for starvation-induced ribophagy".SCIENCE 360.6390(2018):751-+.
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