Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aar2663 |
NUFIP1 is a ribosome receptor for starvation-induced ribophagy | |
Wyant, Gregory A.1,2,3,4,5; Abu-Remaileh, Monther1,2,3,4,5; Frenkel, Evgeni M.1,2,3,4,5; Laqtom, Nouf N.1,2,3,4,5; Dharamdasani, Vimisha1,2,3,4,5; Lewis, Caroline A.1,2; Chan, Sze Ham1,2; Heinze, Ivonne6; Ori, Alessandro6; Sabatini, David M.1,2,3,4,5 | |
2018-05-18 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6390页码:751-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Germany |
英文摘要 | The lysosome degrades and recycles macromolecules, signals to the master growth regulator mTORC1 [mechanistic target of rapamycin (mTOR) complex 1], and is associated with human disease. We performed quantitative proteomic analyses of rapidly isolated lysosomes and found that nutrient levels and mTOR dynamically modulate the lysosomal proteome. Upon mTORC1 inhibition, NUFIP1 (nuclear fragile Xmental retardation-interacting protein 1) redistributes from the nucleus to autophagosomes and lysosomes. Upon these conditions, NUFIP1 interacts with ribosomes and delivers them to autophagosomes by directly binding to microtubule-associated proteins 1A/1B light chain 3B (LC3B). The starvation-induced degradation of ribosomes via autophagy (ribophagy) depends on the capacity of NUFIP1 to bind LC3B and promotes cell survival. We propose that NUFIP1 is a receptor for the selective autophagy of ribosomes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000432473500040 |
WOS关键词 | HEREDITARY SPASTIC PARAPLEGIA ; AUTOPHAGY RECEPTOR ; SELECTIVE AUTOPHAGY ; RAG GTPASES ; LYSOSOMES ; PROTEINS ; CELLS ; YEAST ; MTORC1 ; DEGRADATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198696 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.MIT, Whitehead Inst Biomed Res, Cambridge, MA 02142 USA; 2.MIT, Dept Biol, Cambridge, MA 02142 USA; 3.MIT, Howard Hughes Med Inst, Dept Biol, Cambridge, MA 02139 USA; 4.MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02142 USA; 5.Broad Inst Harvard & MIT, Cambridge, MA 02142 USA; 6.Leibniz Inst Aging, Fritz Lipmann Inst, D-07745 Jena, Germany |
推荐引用方式 GB/T 7714 | Wyant, Gregory A.,Abu-Remaileh, Monther,Frenkel, Evgeni M.,et al. NUFIP1 is a ribosome receptor for starvation-induced ribophagy[J]. SCIENCE,2018,360(6390):751-+. |
APA | Wyant, Gregory A..,Abu-Remaileh, Monther.,Frenkel, Evgeni M..,Laqtom, Nouf N..,Dharamdasani, Vimisha.,...&Sabatini, David M..(2018).NUFIP1 is a ribosome receptor for starvation-induced ribophagy.SCIENCE,360(6390),751-+. |
MLA | Wyant, Gregory A.,et al."NUFIP1 is a ribosome receptor for starvation-induced ribophagy".SCIENCE 360.6390(2018):751-+. |
条目包含的文件 | 条目无相关文件。 |
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