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DOI | 10.1126/science.aar4237 |
Evolution of pallium, hippocampus, and cortical cell types revealed by single-cell transcriptomics in reptiles | |
Tosches, Maria Antonietta1; Yamawaki, Tracy M.1,2; Naumann, Robert K.1,3; Jacobi, Ariel A.1,4; Tushev, Georgi1; Laurent, Gilles1 | |
2018-05-25 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6391页码:881-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; USA; Peoples R China |
英文摘要 | Computations in the mammalian cortex are carried out by glutamatergic and gamma-aminobutyric acid-releasing (GABAergic) neurons forming specialized circuits and areas. Here we asked how these neurons and areas evolved in amniotes. We built a gene expression atlas of the pallium of two reptilian species using large-scale single-cell messenger RNA sequencing. The transcriptomic signature of glutamatergic neurons in reptilian cortex suggests that mammalian neocortical layers are made of new cell types generated by diversification of ancestral gene-regulatory programs. By contrast, the diversity of reptilian cortical GABAergic neurons indicates that the interneuron classes known in mammals already existed in the common ancestor of all amniotes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000433039800042 |
WOS关键词 | CEREBRAL-CORTEX ; RNA-SEQ ; MOUSE ; NEURONS ; TURTLE ; TELENCEPHALON ; ORGANIZATION ; CONNECTIONS ; HOMOLOGIES ; DIVERSITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198742 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Max Planck Inst Brain Res, Max Von Laue Str 4, D-60438 Frankfurt, Germany; 2.Amgen Inc, 1120 Vet Blvd, San Francisco, CA 94080 USA; 3.Shenzhen Univ Town, Shenzhen Inst Adv Tech, Chinese Acad Sci, 1068 Xueyuan Ave, Shenzhen 518055, Peoples R China; 4.Univ Calif Davis, Sch Med, 4610 X St, Sacramento, CA 95817 USA |
推荐引用方式 GB/T 7714 | Tosches, Maria Antonietta,Yamawaki, Tracy M.,Naumann, Robert K.,et al. Evolution of pallium, hippocampus, and cortical cell types revealed by single-cell transcriptomics in reptiles[J]. SCIENCE,2018,360(6391):881-+. |
APA | Tosches, Maria Antonietta,Yamawaki, Tracy M.,Naumann, Robert K.,Jacobi, Ariel A.,Tushev, Georgi,&Laurent, Gilles.(2018).Evolution of pallium, hippocampus, and cortical cell types revealed by single-cell transcriptomics in reptiles.SCIENCE,360(6391),881-+. |
MLA | Tosches, Maria Antonietta,et al."Evolution of pallium, hippocampus, and cortical cell types revealed by single-cell transcriptomics in reptiles".SCIENCE 360.6391(2018):881-+. |
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