Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaq1736 |
Cell type transcriptome atlas for the planarian Schmidtea mediterranea | |
Fincher, Christopher T.1,2,3; Wurtzel, Omri1,2; de Hoog, Thom1,2; Kravarik, Kellie M.1,2,3; Reddien, Peter W.1,2,3 | |
2018-05-25 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6391 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The transcriptome of a cell dictates its unique cell type biology. We used single-cell RNA sequencing to determine the transcriptomes for essentially every cell type of a complete animal: the regenerative planarian Schmidtea mediterranea. Planarians contain a diverse array of cell types, possess lineage progenitors for differentiated cells (including pluripotent stem cells), and constitutively express positional information, making them ideal for this undertaking. We generated data for 66,783 cells, defining transcriptomes for known and many previously unknown planarian cell types and for putative transition states between stem and differentiated cells. We also uncovered regionally expressed genes in muscle, which harbors positional information. Identifying the transcriptomes for potentially all cell types for many organisms should be readily attainable and represents a powerful approach to metazoan biology. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000433039800038 |
WOS关键词 | STEM-CELLS ; GENE-EXPRESSION ; SYSTEM REGENERATION ; EXCRETORY SYSTEM ; RNA-SEQ ; REGULATORS ; MAINTENANCE ; EVOLUTION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198745 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA; 2.MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA; 3.MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA |
推荐引用方式 GB/T 7714 | Fincher, Christopher T.,Wurtzel, Omri,de Hoog, Thom,et al. Cell type transcriptome atlas for the planarian Schmidtea mediterranea[J]. SCIENCE,2018,360(6391). |
APA | Fincher, Christopher T.,Wurtzel, Omri,de Hoog, Thom,Kravarik, Kellie M.,&Reddien, Peter W..(2018).Cell type transcriptome atlas for the planarian Schmidtea mediterranea.SCIENCE,360(6391). |
MLA | Fincher, Christopher T.,et al."Cell type transcriptome atlas for the planarian Schmidtea mediterranea".SCIENCE 360.6391(2018). |
条目包含的文件 | 条目无相关文件。 |
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