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DOI | 10.1126/science.aat3810 |
Synapse-specific representation of the identity of overlapping memory engrams | |
Abdou, Kareem1,2; Shehata, Mohammad1,2,6,7; Choko, Kiriko1,2; Nishizono, Hirofumi2,3; Matsuo, Mina3; Muramatsu, Shin-ichi4,5; Inokuchi, Kaoru1,2 | |
2018-06-15 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6394页码:1227-1231 |
文章类型 | Article |
语种 | 英语 |
国家 | Japan; USA |
英文摘要 | Memories are integrated into interconnected networks; nevertheless, eachmemory has its own identity. How the brain defines specific memory identity out of intermingled memories stored in a shared cell ensemble has remained elusive. We found that after complete retrograde amnesia of auditory fear conditioning in mice, optogenetic stimulation of the auditory inputs to the lateral amygdala failed to induce memory recall, implying that the memory engram no longer existed in that circuit. Complete amnesia of a given fear memory did not affect another linked fear memory encoded in the shared ensemble. Optogenetic potentiation or depotentiation of the plasticity at synapses specific to one memory affected the recall of only that memory. Thus, the sharing of engram cells underlies the linkage between memories, whereas synapse-specific plasticity guarantees the identity and storage of individualmemories. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000435360400052 |
WOS关键词 | LONG-TERM POTENTIATION ; FEAR MEMORY ; PLASTICITY ; AMYGDALA ; STIMULATION ; CIRCUITS ; TRANSMISSION ; HIPPOCAMPUS ; ALLOCATION ; AUTOPHAGY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198888 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Toyama, Grad Sch Med & Pharmaceut Sci, Dept Biochem, Toyama 9300194, Japan; 2.Univ Toyama, Japan Sci & Technol Agcy, CREST, Toyama 9300194, Japan; 3.Univ Toyama, Life Sci Res Ctr, Div Anim Expt Lab, Toyama 9300194, Japan; 4.Jichi Med Univ, Dept Med, Div Nephrol, Shimotsuke, Tochigi 3290498, Japan; 5.Univ Tokyo, Inst Med Sci, Ctr Gene & Cell Therapy, Tokyo 1088639, Japan; 6.CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA; 7.Toyohashi Univ Technol, Mind & Brain Lab Perceptual & Cognit Proc, Toyohashi, Aichi 4418580, Japan |
推荐引用方式 GB/T 7714 | Abdou, Kareem,Shehata, Mohammad,Choko, Kiriko,et al. Synapse-specific representation of the identity of overlapping memory engrams[J]. SCIENCE,2018,360(6394):1227-1231. |
APA | Abdou, Kareem.,Shehata, Mohammad.,Choko, Kiriko.,Nishizono, Hirofumi.,Matsuo, Mina.,...&Inokuchi, Kaoru.(2018).Synapse-specific representation of the identity of overlapping memory engrams.SCIENCE,360(6394),1227-1231. |
MLA | Abdou, Kareem,et al."Synapse-specific representation of the identity of overlapping memory engrams".SCIENCE 360.6394(2018):1227-1231. |
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