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DOI | 10.1126/science.aas9875 |
Reactivation of recall-induced neurons contributes to remote fear memory attenuation | |
Khalaf, Ossama; Resch, Siegfried; Dixsaut, Lucie; Gorden, Victoire; Glauser, Liliane; Graff, Johannes | |
2018-06-15 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6394页码:1239-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland |
英文摘要 | Whether fear attenuation is mediated by inhibition of the original memory trace of fear with a new memory trace of safety or by updating of the original fear trace toward safety has been a long-standing question in neuroscience and psychology alike. In particular, which of the two scenarios underlies the attenuation of remote (month-old) fear memories is completely unknown, despite the impetus to better understand this process against the backdrop of enduring traumata. We found-chemogenetically and in an engram-specific manner-that effective remote fear attenuation is accompanied by the reactivation of memory recall-induced neurons in the dentate gyrus and that the continued activity of these neurons is critical for fear reduction. This suggests that the original memory trace of fear actively contributes to remote fear attenuation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000435360400055 |
WOS关键词 | HIPPOCAMPAL ENGRAM ; DENTATE GYRUS ; EXTINCTION ; RECONSOLIDATION ; CONTEXT ; RETRIEVAL ; CIRCUITS ; MECHANISMS ; ENSEMBLES ; TIME |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198891 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | Ecole Polytech Fed Lausanne, Sch Life Sci, Brain Mind Inst, Lab Neuroepigenet, CH-1015 Lausanne, Switzerland |
推荐引用方式 GB/T 7714 | Khalaf, Ossama,Resch, Siegfried,Dixsaut, Lucie,et al. Reactivation of recall-induced neurons contributes to remote fear memory attenuation[J]. SCIENCE,2018,360(6394):1239-+. |
APA | Khalaf, Ossama,Resch, Siegfried,Dixsaut, Lucie,Gorden, Victoire,Glauser, Liliane,&Graff, Johannes.(2018).Reactivation of recall-induced neurons contributes to remote fear memory attenuation.SCIENCE,360(6394),1239-+. |
MLA | Khalaf, Ossama,et al."Reactivation of recall-induced neurons contributes to remote fear memory attenuation".SCIENCE 360.6394(2018):1239-+. |
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