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DOI | 10.1126/science.aaj1853 |
Induction of CD4 T cell memory by local cellular collectivity | |
Polonsky, Michal1; Rimer, Jacob1; Kern-Perets, Amos1; Zaretsky, Irina1; Miller, Stav1; Bornstein, Chamutal1; David, Eyal1; Kopelman, Naama Meira2,4; Stelzer, Gil2; Porat, Ziv2; Chain, Benjamin3; Friedman, Nir1 | |
2018-06-15 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6394页码:1201-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Israel; England |
英文摘要 | Cell differentiation is directed by signals driving progenitors into specialized cell types. This process can involve collective decision-making, when differentiating cells determine their lineage choice by interacting with each other. We used live-cell imaging in microwell arrays to study collective processes affecting differentiation of naive CD4+ Tcells into memory precursors. We found that differentiation of precursor memory Tcells sharply increases above a threshold number of locally interacting cells. These homotypic interactions involve the cytokines interleukin-2 (IL-2) and IL-6, which affect memory differentiation orthogonal to their effect on proliferation and survival. Mathematical modeling suggests that the differentiation rate is continuously modulated by the instantaneous number of locally interacting cells. This cellular collectivity can prioritize allocation of immune memory to stronger responses. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000435360400045 |
WOS关键词 | LYMPHOCYTE DIVISION ; CD8(+) EFFECTOR ; DIFFERENTIATION ; GENERATION ; INFECTION ; EXPANSION ; ACTIVATION ; EXPRESSION ; IMMUNITY ; SPECIFICATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198904 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Weizmann Inst Sci, Dept Immunol, Rehovot, Israel; 2.Weizmann Inst Sci, Life Sci Core Facil, Rehovot, Israel; 3.UCL, Div Infect & Immun, London, England; 4.Holon Inst Technol, Dept Comp Sci, Holon, Israel |
推荐引用方式 GB/T 7714 | Polonsky, Michal,Rimer, Jacob,Kern-Perets, Amos,et al. Induction of CD4 T cell memory by local cellular collectivity[J]. SCIENCE,2018,360(6394):1201-+. |
APA | Polonsky, Michal.,Rimer, Jacob.,Kern-Perets, Amos.,Zaretsky, Irina.,Miller, Stav.,...&Friedman, Nir.(2018).Induction of CD4 T cell memory by local cellular collectivity.SCIENCE,360(6394),1201-+. |
MLA | Polonsky, Michal,et al."Induction of CD4 T cell memory by local cellular collectivity".SCIENCE 360.6394(2018):1201-+. |
条目包含的文件 | 条目无相关文件。 |
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