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DOI | 10.1126/science.aao0862 |
Locally coordinated synaptic plasticity of visual cortex neurons in vivo | |
El-Boustani, Sami1,5; Ip, Jacque P. K.1; Breton-Provencher, Vincent1; Knott, Graham W.2; Okuno, Hiroyuki3,6; Bito, Haruhiko4; Sur, Mriganka1 | |
2018-06-22 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6395页码:1349-1354 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Switzerland; Japan |
英文摘要 | Plasticity of cortical responses in vivo involves activity-dependent changes at synapses, but the manner in which different forms of synaptic plasticity act together to create functional changes in neurons remains unknown. We found that spike timing-induced receptive field plasticity of visual cortex neurons in mice is anchored by increases in the synaptic strength of identified spines. This is accompanied by a decrease in the strength of adjacent spines on a slower time scale. The locally coordinated potentiation and depression of spines involves prominent AMPA receptor redistribution via targeted expression of the immediate early gene product Arc. Hebbian strengthening of activated synapses and heterosynaptic weakening of adjacent synapses thus cooperatively orchestrate cell-wide plasticity of functional neuronal responses. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000436040600044 |
WOS关键词 | LONG-TERM POTENTIATION ; HOMEOSTATIC PLASTICITY ; MOTOR CORTEX ; SYNAPSES ; TRAFFICKING ; DEPRIVATION ; EXPERIENCE ; ARC/ARG3.1 ; DENDRITES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198952 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.MIT, Picower Inst Learning & Memory, Dept Brain & Cognit Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA; 2.Ecole Polytech Fed Lausanne, Sch Life Sci, Bio Electron Microscopy Lab, CH-1015 Lausanne, Switzerland; 3.Kyoto Univ, Grad Sch Med, Med Innovat Ctr, Sakyo Ku, Kyoto 6068507, Japan; 4.Univ Tokyo, Grad Sch Med, Dept Neurochem, Bunkyo Ku, Hongo 7-3-1, Tokyo 1130033, Japan; 5.Ecole Polytech Fed Lausanne, Sch Life Sci, Brain Mind Inst, CH-1015 Lausanne, Switzerland; 6.Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Biochem & Mol Biol, 8-35-1 Sakuragaoka, Kagoshima 8908544, Japan |
推荐引用方式 GB/T 7714 | El-Boustani, Sami,Ip, Jacque P. K.,Breton-Provencher, Vincent,et al. Locally coordinated synaptic plasticity of visual cortex neurons in vivo[J]. SCIENCE,2018,360(6395):1349-1354. |
APA | El-Boustani, Sami.,Ip, Jacque P. K..,Breton-Provencher, Vincent.,Knott, Graham W..,Okuno, Hiroyuki.,...&Sur, Mriganka.(2018).Locally coordinated synaptic plasticity of visual cortex neurons in vivo.SCIENCE,360(6395),1349-1354. |
MLA | El-Boustani, Sami,et al."Locally coordinated synaptic plasticity of visual cortex neurons in vivo".SCIENCE 360.6395(2018):1349-1354. |
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