Regulation of feeding by somatostatin neurons in the tuberal nucleus

doi:10.1126/science.aar4983

GSTDTAP > 地球科学

DOI	10.1126/science.aar4983
	Regulation of feeding by somatostatin neurons in the tuberal nucleus
	Luo, Sarah Xinwei 1; Huang, Ju 2,3; Li, Qin 1,4; Mohammad, Hasan 1; Lee, Chun-Yao 1; Krishna, Kumar 5; Kok, Alison Maun-Yeng 1; Tan, Yu Lin 1; Lim, Joy Yi 1; Li, Hongyu 1; Yeow, Ling Yun 1; Sun, Jingjing 2,3; He, Miao 6; Grandjean, Joanes 1; Sajikumar, Sreedharan 5; Han, Weiping 1; Fu, Yu 1,5
	2018-07-06
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2018
卷号	361 期号:6397 页码:76-+
文章类型	Article
语种	英语
国家	Singapore; Peoples R China
英文摘要	The tuberal nucleus (TN) is a surprisingly understudied brain region. We found that somatostatin (SST) neurons in the TN, which is known to exhibit pathological or cytological changes in human neurodegenerative diseases, play a crucial role in regulating feeding in mice. GABAergic tuberal SST ((SST)-S-TN) neurons were activated by hunger and by the hunger hormone, ghrelin. Activation of (TN)SSTneurons promoted feeding, whereas inhibition reduced it via projections to the paraventricular nucleus and bed nucleus of the stria terminalis. Ablation of (TN)SSTneurons reduced body weight gain and food intake. These findings reveal a previously unknown mechanism of feeding regulation that operates through orexigenic (TN)SSTneurons, providing a new perspective for understanding appetite changes.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000437467100064
WOS关键词	CYTOSKELETAL CHANGES ; HUNTINGTONS-DISEASE ; ADULT MICE ; HYPOTHALAMUS ; CIRCUIT ; BEHAVIOR ; ANOREXIA ; HUNGER
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/199081
专题	地球科学资源环境科学气候变化
作者单位	1.ASTAR, Singapore Bioimaging Consortium, Singapore 138667, Singapore; 2.Shanghai Jiao Tong Univ, Sch Med, Discipline Neurosci, Shanghai 200025, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, Dept Anat Histol & Embryol, Shanghai 200025, Peoples R China; 4.Chinese Acad Sci, Wuhan Inst Phys & Math, Key Lab Magnet Resonance Biol Syst, Ctr Brain Sci, Wuhan 430071, Hubei, Peoples R China; 5.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore 117597, Singapore; 6.Fudan Univ, State Key Lab Med Neurobiol, Inst Brain Sci, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Luo, Sarah Xinwei,Huang, Ju,Li, Qin,et al. Regulation of feeding by somatostatin neurons in the tuberal nucleus[J]. SCIENCE,2018,361(6397):76-+.
APA	Luo, Sarah Xinwei.,Huang, Ju.,Li, Qin.,Mohammad, Hasan.,Lee, Chun-Yao.,...&Fu, Yu.(2018).Regulation of feeding by somatostatin neurons in the tuberal nucleus.SCIENCE,361(6397),76-+.
MLA	Luo, Sarah Xinwei,et al."Regulation of feeding by somatostatin neurons in the tuberal nucleus".SCIENCE 361.6397(2018):76-+.