Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aat6365 |
Deconstructive fluorination of cyclic amines by carbon-carbon cleavage | |
Roque, Jose B.; Kuroda, Yusuke; Gottemann, Lucas T.; Sarpong, Richmond | |
2018-07-13 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6398页码:171-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Deconstructive functionalizations involving scission of carbon-carbon double bonds are well established. In contrast, unstrained C(sp(3))-C(sp(3)) bond cleavage and functionalization have less precedent. Here we report the use of deconstructive fluorination to access mono-and difluorinated amine derivatives by C(sp(3))-C(sp(3)) bond cleavage in saturated nitrogen heterocycles such as piperidines and pyrrolidines. Silver-mediated ring-opening fluorination using Selectfluor highlights a strategy for cyclic amine functionalization and late-stage skeletal diversification, establishing cyclic amines as synthons for amino alkyl radicals and providing synthetic routes to valuable building blocks. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000438449200043 |
WOS关键词 | CATALYZED DECARBOXYLATIVE FLUORINATION ; MEDICINAL CHEMISTRY ; ACIDS ; DERIVATIVES ; OXIDATION ; PEPTIDES ; DIVERSIFICATION ; PHARMACEUTICALS ; DIVERSITY ; COMPLEXES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199140 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA |
推荐引用方式 GB/T 7714 | Roque, Jose B.,Kuroda, Yusuke,Gottemann, Lucas T.,et al. Deconstructive fluorination of cyclic amines by carbon-carbon cleavage[J]. SCIENCE,2018,361(6398):171-+. |
APA | Roque, Jose B.,Kuroda, Yusuke,Gottemann, Lucas T.,&Sarpong, Richmond.(2018).Deconstructive fluorination of cyclic amines by carbon-carbon cleavage.SCIENCE,361(6398),171-+. |
MLA | Roque, Jose B.,et al."Deconstructive fluorination of cyclic amines by carbon-carbon cleavage".SCIENCE 361.6398(2018):171-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论