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DOI | 10.1126/science.aat1178 |
A molecular mechanism for Wnt ligand-specific signaling | |
Eubelen, Marie1; Bostaille, Naguissa1; Cabochette, Pauline1; Gauquier, Anne1; Tebabi, Patricia1; Dumitru, Andra C.2; Koehler, Melanie2; Gut, Philipp1,7; Alsteens, David2; Stainier, Didier Y. R.3; Garcia-Pino, Abel4,5; Vanhollebeke, Benoit1,5,6 | |
2018-08-17 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6403页码:663-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Belgium; Germany; Switzerland |
英文摘要 | Wnt signaling is key to many developmental, physiological, and disease processes in which cells seem able to discriminate between multiple Wnt ligands. This selective Wnt recognition or "decoding" capacity has remained enigmatic because Wnt/Frizzled interactions are largely incompatible with monospecific recognition. Gpr124 and Reck enable brain endothelial cells to selectively respond to Wnt7. We show that Reck binds with low micromolar affinity to the intrinsically disordered linker region of Wnt7. Availability of Reck-bound Wnt7 for Frizzled signaling relies on the interaction between Gpr124 and Dishevelled. Through polymerization, Dishevelled recruits Gpr124 and the associated Reck-bound Wnt7 into dynamic Wnt/Frizzled/Lrp5/6 signalosomes, resulting in increased local concentrations of Wnt7 available for Frizzled signaling. This work provides mechanistic insights into the Wnt decoding capacities of vertebrate cells and unravels structural determinants of the functional diversification of Wnt family members. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000442818200034 |
WOS关键词 | PROTEIN-COUPLED RECEPTOR ; BRAIN-BARRIER INTEGRITY ; CNS ANGIOGENESIS ; GPR124 ; PATHWAY ; RECK ; TAIL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199380 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.ULB, ULB Neurosci Inst, Dept Mol Biol, Lab Neurovasc Signaling, B-6041 Gosselies, Belgium; 2.Catholic Univ Louvain, Louvain Inst Biomol Sci & Technol, NanoBiophys Lab, B-1348 Louvain La Neuve, Belgium; 3.Max Planck Inst Heart & Lung Res, Dept Dev Genet, D-61231 Bad Nauheim, Germany; 4.ULB, Dept Mol Biol, Lab Cellular & Mol Microbiol, B-6041 Gosselies, Belgium; 5.Walloon Excellence Life Sci & Biotechnol WELBIO, Gosselies, Belgium; 6.ULB, CMMI, B-6041 Gosselies, Belgium; 7.Nestle Inst Hlth Sci, EPFL Innovat Pk, Lausanne, Switzerland |
推荐引用方式 GB/T 7714 | Eubelen, Marie,Bostaille, Naguissa,Cabochette, Pauline,et al. A molecular mechanism for Wnt ligand-specific signaling[J]. SCIENCE,2018,361(6403):663-+. |
APA | Eubelen, Marie.,Bostaille, Naguissa.,Cabochette, Pauline.,Gauquier, Anne.,Tebabi, Patricia.,...&Vanhollebeke, Benoit.(2018).A molecular mechanism for Wnt ligand-specific signaling.SCIENCE,361(6403),663-+. |
MLA | Eubelen, Marie,et al."A molecular mechanism for Wnt ligand-specific signaling".SCIENCE 361.6403(2018):663-+. |
条目包含的文件 | 条目无相关文件。 |
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