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DOI | 10.1126/science.aaq1327 |
Co-regulatory networks of human serum proteins link genetics to disease | |
Emilsson, Valur1,2; Ilkov, Marjan1; Lamb, John R.3; Finkel, Nancy4; Gudmundsson, Elias F.1; Pitts, Rebecca4; Hoover, Heather4; Gudmundsdottir, Valborg1; Horman, Shane R.3; Aspelund, Thor1,5; Shu, Le6; Trifonov, Vladimir3; Sigurdsson, Sigurdur1; Manolescu, Andrei7; Zhu, Jun8; Olafsson, Orn1; Jakobsdottir, Johanna1; Lesley, Scott A.3; To, Jeremy3; Zhang, Jia3; Harris, Tamara B.9; Launer, Lenore J.9; Zhang, Bin8; Eiriksdottir, Gudny1; Yang, Xia6; Orth, Anthony P.3; Jennings, Lori L.4; Gudnason, Vilmundur1,10 | |
2018-08-24 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6404页码:769-773 |
文章类型 | Article |
语种 | 英语 |
国家 | Iceland; USA |
英文摘要 | Proteins circulating in the blood are critical for age-related disease processes; however, the serum proteome has remained largely unexplored. To this end, 4137 proteins covering most predicted extracellular proteins were measured in the serum of 5457 Icelanders over 65 years of age. Pairwise correlation between proteins as they varied across individuals revealed 27 different network modules of serum proteins, many of which were associated with cardiovascular and metabolic disease states, as well as overall survival. The protein modules were controlled by cis- and trans-acting genetic variants, which in many cases were also associated with complex disease. This revealed co-regulated groups of circulating proteins that incorporated regulatory control between tissues and demonstrated close relationships to past, current, and future disease states. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000442828700037 |
WOS关键词 | MOLECULAR NETWORKS ; EXPRESSION ; DATABASE ; AGE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199436 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Iceland Heart Assoc, Holtasmari 1, IS-201 Kopavogur, Iceland; 2.Univ Iceland, Fac Pharmacol, IS-101 Reykjavik, Iceland; 3.Novartis Res Fdn, Genom Inst, 10675 John Jay Hopkins Dr, San Diego, CA 92121 USA; 4.Novartis Inst Biomed Res, 22 Windsor St, Cambridge, MA 02139 USA; 5.Univ Iceland, Ctr Publ Hlth Sci, IS-101 Reykjavik, Iceland; 6.Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA USA; 7.Reykjavik Univ, Sch Sci & Engn, Mentavegur 1, IS-101 Reykjavik, Iceland; 8.Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA; 9.NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, Bethesda, MD 20892 USA; 10.Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland |
推荐引用方式 GB/T 7714 | Emilsson, Valur,Ilkov, Marjan,Lamb, John R.,et al. Co-regulatory networks of human serum proteins link genetics to disease[J]. SCIENCE,2018,361(6404):769-773. |
APA | Emilsson, Valur.,Ilkov, Marjan.,Lamb, John R..,Finkel, Nancy.,Gudmundsson, Elias F..,...&Gudnason, Vilmundur.(2018).Co-regulatory networks of human serum proteins link genetics to disease.SCIENCE,361(6404),769-773. |
MLA | Emilsson, Valur,et al."Co-regulatory networks of human serum proteins link genetics to disease".SCIENCE 361.6404(2018):769-773. |
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