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DOI | 10.1126/science.aao2861 |
Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system | |
Segarra, Marta1,2; Aburto, Maria R.1,2,3; Cop, Florian1,2; Llao-Cid, Cecilia1,2; Haertl, Ricarda1,2; Damm, Miriam1,2,3; Bethani, Ioanna1,2; Parrilla, Marta1,2,4; Husainie, Dewi1,2,4; Schaenzer, Anne5; Schlierbach, Hannah5; Acker, Till5; Mohr, Laura1,2; Torres-Masjoan, Laia1,2; Ritter, Mathias1,2; Acker-Palmer, Amparo1,2,3,4 | |
2018-08-24 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6404 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany |
英文摘要 | The architecture of the neurovascular unit (NVU) is controlled by the communication of neurons, glia, and vascular cells. We found that the neuronal guidance cue reelin possesses proangiogenic activities that ensure the communication of endothelial cells (ECs) with the glia to control neuronal migration and the establishment of the blood-brain barrier in the mouse brain. Apolipoprotein E receptor 2 (ApoER2) and Disabled1 (Dab1) expressed in ECs are required for vascularization of the retina and the cerebral cortex. Deletion of Dab1 in ECs leads to a reduced secretion of laminin-alpha 4 and decreased activation of integrin-beta 1 in glial cells, which in turn control neuronal migration and barrier properties of the NVU. Thus, reelin signaling in the endothelium is an instructive and integrative cue essential for neuro-glia-vascular communication. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000442828700035 |
WOS关键词 | BLOOD-BRAIN-BARRIER ; BASEMENT-MEMBRANE ; LAMINAR ORGANIZATION ; REELIN EXPRESSION ; MATRIX ADHESION ; VLDL RECEPTOR ; CELL-ADHESION ; MIGRATION ; ANGIOGENESIS ; ACTIVATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199438 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Goethe Univ Frankfurt, Inst Cell Biol & Neurosci, D-60438 Frankfurt, Germany; 2.Goethe Univ Frankfurt, Buchmann Inst Mol Life Sci, D-60438 Frankfurt, Germany; 3.Johannes Gutenberg Univ Mainz, Focus Program Translat Neurosci, D-55131 Mainz, Germany; 4.Max Planck Inst Brain Res, D-60438 Frankfurt, Germany; 5.Univ Giessen, Inst Neuropathol, D-35392 Giessen, Germany |
推荐引用方式 GB/T 7714 | Segarra, Marta,Aburto, Maria R.,Cop, Florian,et al. Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system[J]. SCIENCE,2018,361(6404). |
APA | Segarra, Marta.,Aburto, Maria R..,Cop, Florian.,Llao-Cid, Cecilia.,Haertl, Ricarda.,...&Acker-Palmer, Amparo.(2018).Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system.SCIENCE,361(6404). |
MLA | Segarra, Marta,et al."Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system".SCIENCE 361.6404(2018). |
条目包含的文件 | 条目无相关文件。 |
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