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DOI | 10.1126/science.aar8174 |
An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast | |
Hansen, Katja G.1; Aviram, Naama2; Laborenz, Janina1; Bibi, Chen2; Meyer, Maren1; Spang, Anne3; Schuldiner, Maya2; Herrmann, Johannes M.1 | |
2018-09-14 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6407页码:1118-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; Israel; Switzerland |
英文摘要 | The majority of organellar proteins are translated on cytosolic ribosomes and must be sorted correctly to function. Targeting routes have been identified for organelles such as peroxisomes and the endoplasmic reticulum (ER). However, little is known about the initial steps of targeting of mitochondrial proteins. In this study, we used a genome-wide screen in yeast and identified factors critical for the intracellular sorting of themitochondrial inner membrane protein Oxa1. The screen uncovered an unexpected path, termed ER-SURF, for targeting of mitochondrial membrane proteins. This pathway retrieves mitochondrial proteins from the ER surface and reroutes them to mitochondria with the aid of the ER-localized chaperone Djp1. Hence, cells use the expanse of the ER surfaces as a fail-safe to maximize productive mitochondrial protein targeting. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000444513300042 |
WOS关键词 | TAIL-ANCHORED PROTEINS ; SPECIFICITY ; LOCALIZATION ; DEGRADATION ; CHAPERONES ; CYTOSOL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199587 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Kaiserslautern, Div Cell Biol, Kaiserslautern, Germany; 2.Weizmann Inst Sci, Dept Mol Genet, Rehovot, Israel; 3.Univ Basel, Biozentrum, Basel, Switzerland |
推荐引用方式 GB/T 7714 | Hansen, Katja G.,Aviram, Naama,Laborenz, Janina,et al. An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast[J]. SCIENCE,2018,361(6407):1118-+. |
APA | Hansen, Katja G..,Aviram, Naama.,Laborenz, Janina.,Bibi, Chen.,Meyer, Maren.,...&Herrmann, Johannes M..(2018).An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast.SCIENCE,361(6407),1118-+. |
MLA | Hansen, Katja G.,et al."An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast".SCIENCE 361.6407(2018):1118-+. |
条目包含的文件 | 条目无相关文件。 |
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