Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aau1646 |
RNA modifications modulate gene expression during development | |
Frye, Michaela1,2; Harada, Bryan T.3,4,5; Behm, Mikaela1; He, Chuan3,4,5,6 | |
2018-09-28 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6409页码:1346-1349 |
文章类型 | Review |
语种 | 英语 |
国家 | England; Germany; USA |
英文摘要 | RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programs. They affect diverse eukaryotic biological processes, and the correct deposition of many of these modifications is required for normal development. Messenger RNA ( mRNA) modifications regulate various aspects of mRNA metabolism. For example, N-6-methyladenosine (m(6)A) affects the translation and stability of the modified transcripts, thus providing a mechanism to coordinate the regulation of groups of transcripts during cell state maintenance and transition. Similarly, some modifications in transfer RNAs are essential for RNA structure and function. Others are deposited in response to external cues and adapt global protein synthesis and gene-specific translation accordingly and thereby facilitate proper development. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000446142200043 |
WOS关键词 | EMBRYONIC STEM-CELLS ; PROTEIN-SYNTHESIS ; MITOCHONDRIAL TRANSLATION ; HEMATOPOIETIC STEM ; SEX DETERMINATION ; BREAST-CANCER ; SELF-RENEWAL ; M(6)A ; METHYLATION ; DIFFERENTIATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199674 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Cambridge, Dept Genet, Downing St, Cambridge CB2 3EH, England; 2.German Canc Ctr DKFZ, Neuenheimer Feld 280, D-69120 Heidelberg, Germany; 3.Univ Chicago, Dept Chem, 5735 S Ellis Ave, Chicago, IL 60637 USA; 4.Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USA; 5.Univ Chicago, Howard Hughes Med Inst, 5841 S Maryland Ave, Chicago, IL 60637 USA; 6.Univ Chicago, Dept Biochem & Mol Biol, 920 E 58Th St, Chicago, IL 60637 USA |
推荐引用方式 GB/T 7714 | Frye, Michaela,Harada, Bryan T.,Behm, Mikaela,et al. RNA modifications modulate gene expression during development[J]. SCIENCE,2018,361(6409):1346-1349. |
APA | Frye, Michaela,Harada, Bryan T.,Behm, Mikaela,&He, Chuan.(2018).RNA modifications modulate gene expression during development.SCIENCE,361(6409),1346-1349. |
MLA | Frye, Michaela,et al."RNA modifications modulate gene expression during development".SCIENCE 361.6409(2018):1346-1349. |
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