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DOI | 10.1126/science.aau0294 |
MCM2 promotes symmetric inheritance of modified histones during DNA replication | |
Petryk, Nataliya1,2; Dalby, Maria3; Wenger, Alice1,2; Stromme, Caroline B.1,4; Strandsby, Anne1,5; Andersson, Robin3; Groth, Anja1,2 | |
2018-09-28 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6409页码:1389-1391 |
文章类型 | Article |
语种 | 英语 |
国家 | Denmark |
英文摘要 | During genome replication, parental histones are recycled to newly replicated DNA with their posttranslational modifications (PTMs). Whether sister chromatids inherit modified histones evenly remains unknown. We measured histone PTM partition to sister chromatids in embryonic stem cells. We found that parental histones H3-H4 segregate to both daughter DNA strands with a weak leading-strand bias, skewing partition at topologically associating domain (TAD) borders and enhancers proximal to replication initiation zones. Segregation of parental histones to the leading strand increased markedly in cells with histone-binding mutations in MCM2, part of the replicative helicase, exacerbating histone PTM sister chromatid asymmetry. This work reveals how histones are inherited to sister chromatids and identifies a mechanism by which the replication machinery ensures symmetric cell division. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000446142200051 |
WOS关键词 | EUKARYOTIC CMG HELICASE ; HUMAN GENOME ; CHROMATIN ; ENHANCERS ; DOMAINS ; FORK ; PTMS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199678 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Copenhagen, Fac Hlth & Med Sci, BRIC, DK-2200 Copenhagen, Denmark; 2.Univ Copenhagen, Fac Hlth & Med Sci, CPR, Novo Nordisk Fdn, DK-2200 Copenhagen, Denmark; 3.Univ Copenhagen, Dept Biol, Bioinformat Ctr, Fac Sci, DK-2200 Copenhagen, Denmark; 4.Novo Nordisk, DK-2860 Soborg, Denmark; 5.Statens Serum Inst, Virus & Microbiol Special Diagnost, DK-2300 Copenhagen S, Denmark |
推荐引用方式 GB/T 7714 | Petryk, Nataliya,Dalby, Maria,Wenger, Alice,et al. MCM2 promotes symmetric inheritance of modified histones during DNA replication[J]. SCIENCE,2018,361(6409):1389-1391. |
APA | Petryk, Nataliya.,Dalby, Maria.,Wenger, Alice.,Stromme, Caroline B..,Strandsby, Anne.,...&Groth, Anja.(2018).MCM2 promotes symmetric inheritance of modified histones during DNA replication.SCIENCE,361(6409),1389-1391. |
MLA | Petryk, Nataliya,et al."MCM2 promotes symmetric inheritance of modified histones during DNA replication".SCIENCE 361.6409(2018):1389-1391. |
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