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DOI | 10.1126/science.aas9435 |
Neuronal specification in space and time | |
Holguera, Isabel1; Desplan, Claude1,2 | |
2018-10-12 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6411页码:176-180 |
文章类型 | Review |
语种 | 英语 |
国家 | USA; U Arab Emirates |
英文摘要 | To understand how neurons assemble to form functional circuits, it is necessary to obtain a detailed knowledge of their diversity and to define the developmental specification programs that give rise to this diversity. Invertebrates and vertebrates appear to share common developmental principles of neuronal specification in which cascades of transcription factors temporally pattern progenitors, while spatial cues modify the outcomes of this temporal patterning. Here, we highlight these conserved mechanisms and describe how they are used in distinct neural structures. We present the questions that remain for a better understanding of neuronal specification. Single-cell RNA profiling approaches will potentially shed light on these questions, allowing not only the characterization of neuronal diversity in adult brains, but also the investigation of the developmental trajectories leading to the generation and maintenance of this diversity. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000447337200042 |
WOS关键词 | SINGLE-CELL TRANSCRIPTOMICS ; SUBTYPE SPECIFICATION ; NEURAL PROGENITORS ; CEREBRAL-CORTEX ; DROSOPHILA ; NEUROGENESIS ; DIVERSITY ; IDENTITY ; LINEAGE ; CLASSIFICATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199823 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.NYU, Dept Biol, New York, NY 10003 USA; 2.New York Univ Abu Dhabi, Ctr Genom & Syst Biol, Abu Dhabi, U Arab Emirates |
推荐引用方式 GB/T 7714 | Holguera, Isabel,Desplan, Claude. Neuronal specification in space and time[J]. SCIENCE,2018,362(6411):176-180. |
APA | Holguera, Isabel,&Desplan, Claude.(2018).Neuronal specification in space and time.SCIENCE,362(6411),176-180. |
MLA | Holguera, Isabel,et al."Neuronal specification in space and time".SCIENCE 362.6411(2018):176-180. |
条目包含的文件 | 条目无相关文件。 |
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