GSTDTAP  > 地球科学
DOI10.1126/science.aap8236
Dimerization quality control ensures neuronal development and survival
Mena, Elijah L.1; Kjolby, Rachel A. S.1; Saxton, Robert A.1,4; Werner, Achim2; Lew, Brandon G.1; Boyle, John M.1; Harland, Richard1; Rape, Michael1,3
2018-10-12
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2018
卷号362期号:6411页码:198-+
文章类型Article
语种英语
国家USA
英文摘要

Aberrant complex formation by recurrent interaction modules, such as BTB domains, leucine zippers, or coiled coils, can disrupt signal transduction, yet whether cells detect and eliminate complexes of irregular composition is unknown. By searching for regulators of the BTB family, we discovered a quality control pathway that ensures functional dimerization [dimerization quality control (DQC)]. Key to this network is the E3 ligase SCFFBXL17, which selectively binds and ubiquitylates BTB dimers of aberrant composition to trigger their clearance by proteasomal degradation. Underscoring the physiological importance of DQC, SCFFBXL17 is required for the differentiation, function, and survival of neural crest and neuronal cells. We conclude that metazoan organisms actively monitor BTB dimerization, and we predict that distinct E3 ligases similarly control complex formation by other recurrent domains.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000447337200047
WOS关键词UBIQUITIN-DEPENDENT REGULATION ; TRANSCRIPTION FACTORS ; HUMAN INTERACTOME ; POZ DOMAIN ; LIGASE ; COMPLEXES ; MECHANISM ; DISEASE ; ADAPTER ; MUTATIONS
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/199827
专题地球科学
资源环境科学
气候变化
作者单位1.Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA;
2.NIDCR, NIH, Bethesda, MD 20892 USA;
3.Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA;
4.Stanford Univ, Sch Med, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA
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Mena, Elijah L.,Kjolby, Rachel A. S.,Saxton, Robert A.,et al. Dimerization quality control ensures neuronal development and survival[J]. SCIENCE,2018,362(6411):198-+.
APA Mena, Elijah L..,Kjolby, Rachel A. S..,Saxton, Robert A..,Werner, Achim.,Lew, Brandon G..,...&Rape, Michael.(2018).Dimerization quality control ensures neuronal development and survival.SCIENCE,362(6411),198-+.
MLA Mena, Elijah L.,et al."Dimerization quality control ensures neuronal development and survival".SCIENCE 362.6411(2018):198-+.
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