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DOI | 10.1126/science.aau7735 |
Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes | |
Ramrath, David J. F.1; Niemann, Moritz2; Leibundgut, Marc1; Bieri, Philipp1; Prange, Celine1; Horn, Elke K.2; Leitner, Alexander3; Boehringer, Daniel1; Schneider, Andre2; Ban, Nenad1 | |
2018-10-26 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6413 |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland |
英文摘要 | Ribosomal RNA (rRNA) plays key functional and architectural roles in ribosomes. Using electron microscopy, we determined the atomic structure of a highly divergent ribosome found in mitochondria of Trypanosoma brucei, a unicellular parasite that causes sleeping sickness in humans. The trypanosomal mitoribosome features the smallest rRNAs and contains more proteins than all known ribosomes. The structure shows how the proteins have taken over the role of architectural scaffold from the rRNA: They form an autonomous outer shell that surrounds the entire particle and stabilizes and positions the functionally important regions of the rRNA. Our results also reveal the "minimal" set of conserved rRNA and protein components shared by all ribosomes that help us define the most essential functional elements. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000450441900041 |
WOS关键词 | PENTATRICOPEPTIDE REPEAT PROTEINS ; TRANSFER-RNA ; KINETOPLAST DNA ; MESSENGER-RNA ; BRUCEI ; TRANSLATION ; SUBUNIT ; 9S ; TRANSLOCATION ; COMPLEXES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199919 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Swiss Fed Inst Technol, Inst Mol Biol & Biophys, Dept Biol, Otto Stern Weg 5, CH-8093 Zurich, Switzerland; 2.Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland; 3.Swiss Fed Inst Technol, Inst Mol Syst Biol, Dept Biol, Auguste Piccard Hof 1, CH-8093 Zurich, Switzerland |
推荐引用方式 GB/T 7714 | Ramrath, David J. F.,Niemann, Moritz,Leibundgut, Marc,et al. Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes[J]. SCIENCE,2018,362(6413). |
APA | Ramrath, David J. F..,Niemann, Moritz.,Leibundgut, Marc.,Bieri, Philipp.,Prange, Celine.,...&Ban, Nenad.(2018).Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.SCIENCE,362(6413). |
MLA | Ramrath, David J. F.,et al."Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes".SCIENCE 362.6413(2018). |
条目包含的文件 | 条目无相关文件。 |
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