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DOI | 10.1126/science.aat0481 |
Dynamic salience processing in paraventricular thalamus gates associative learning | |
Zhu, Yingjie1,2; Nachtrab, Gregory1; Keyes, Piper C.1,3; Allen, William E.1,3; Luo, Liqun1,4; Chen, Xiaoke1 | |
2018-10-26 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6413页码:423-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Peoples R China |
英文摘要 | The salience of behaviorally relevant stimuli is dynamic and influenced by internal state and external environment. Monitoring such changes is critical for effective learning and flexible behavior, but the neuronal substrate for tracking the dynamics of stimulus salience is obscure. We found that neurons in the paraventricular thalamus (PVT) are robustly activated by a variety of behaviorally relevant events, including novel ("unfamiliar") stimuli, reinforcing stimuli and their predicting cues, as well as omission of the expected reward. PVT responses are scaled with stimulus intensity and modulated by changes in homeostatic state or behavioral context. Inhibition of the PVT responses suppresses appetitive or aversive associative learning and reward extinction. Our findings demonstrate that the PVT gates associative learning by providing a dynamic representation of stimulus salience. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000450441900042 |
WOS关键词 | NUCLEUS-ACCUMBENS ; DOPAMINE NEURONS ; PARIETAL CORTEX ; PRIORITY MAP ; REWARD ; ATTENTION ; BEHAVIOR ; MAINTENANCE ; PROJECTIONS ; CIRCUITS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199933 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Dept Biol, Stanford, CA 94305 USA; 2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Brain Cognit & Brain Dis Inst, Guangdong Prov Key Lab Brain Connectome & Behav, Shenzhen 518055, Peoples R China; 3.Stanford Univ, Neurosci Program, Stanford, CA 94305 USA; 4.Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Zhu, Yingjie,Nachtrab, Gregory,Keyes, Piper C.,et al. Dynamic salience processing in paraventricular thalamus gates associative learning[J]. SCIENCE,2018,362(6413):423-+. |
APA | Zhu, Yingjie,Nachtrab, Gregory,Keyes, Piper C.,Allen, William E.,Luo, Liqun,&Chen, Xiaoke.(2018).Dynamic salience processing in paraventricular thalamus gates associative learning.SCIENCE,362(6413),423-+. |
MLA | Zhu, Yingjie,et al."Dynamic salience processing in paraventricular thalamus gates associative learning".SCIENCE 362.6413(2018):423-+. |
条目包含的文件 | 条目无相关文件。 |
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