GSTDTAP  > 地球科学
DOI10.1126/science.aau4832
Identity inference of genomic data using long-range familial searches
Erlich, Yaniv1; 39;er, Itsik2
2018-11-09
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2018
卷号362期号:6415页码:690-+
文章类型Article
语种英语
国家Israel; USA
英文摘要

Consumer genomics databases have reached the scale of millions of individuals. Recently, law enforcement authorities have exploited some of these databases to identify suspects via distant familial relatives. Using genomic data of 1.28 million individuals tested with consumer genomics, we investigated the power of this technique. We project that about 60% of the searches for individuals of European descent will result in a third-cousin or closer match, which theoretically allows their identification using demographic identifiers. Moreover, the technique could implicate nearly any U.S. individual of European descent in the near future. We demonstrate that the technique can also identify research participants of a public sequencing project. On the basis of these results, we propose a potential mitigation strategy and policy implications for human subject research.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000450474500042
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
被引频次:188[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/200025
专题地球科学
资源环境科学
气候变化
作者单位1.MyHeritage, IL-6037606 Or Yehuda, Israel;
2.Columbia Univ, Dept Comp Sci, Fu Fdn Sch Engn, New York, NY 10027 USA;
3.Columbia Univ, Dept Syst Biol, Ctr Computat Biol & Bioinformat C2B2, New York, NY 10027 USA;
4.New York Genome Ctr, New York, NY 10013 USA;
5.Hebrew Univ Jerusalem, Braun Sch Publ Hlth & Community Med, Jerusalem, Israel
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Erlich, Yaniv,39;er, Itsik. Identity inference of genomic data using long-range familial searches[J]. SCIENCE,2018,362(6415):690-+.
APA Erlich, Yaniv,&39;er, Itsik.(2018).Identity inference of genomic data using long-range familial searches.SCIENCE,362(6415),690-+.
MLA Erlich, Yaniv,et al."Identity inference of genomic data using long-range familial searches".SCIENCE 362.6415(2018):690-+.
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