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DOI | 10.1126/science.aau4832 |
Identity inference of genomic data using long-range familial searches | |
Erlich, Yaniv1; 39;er, Itsik2 | |
2018-11-09 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6415页码:690-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Israel; USA |
英文摘要 | Consumer genomics databases have reached the scale of millions of individuals. Recently, law enforcement authorities have exploited some of these databases to identify suspects via distant familial relatives. Using genomic data of 1.28 million individuals tested with consumer genomics, we investigated the power of this technique. We project that about 60% of the searches for individuals of European descent will result in a third-cousin or closer match, which theoretically allows their identification using demographic identifiers. Moreover, the technique could implicate nearly any U.S. individual of European descent in the near future. We demonstrate that the technique can also identify research participants of a public sequencing project. On the basis of these results, we propose a potential mitigation strategy and policy implications for human subject research. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000450474500042 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200025 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.MyHeritage, IL-6037606 Or Yehuda, Israel; 2.Columbia Univ, Dept Comp Sci, Fu Fdn Sch Engn, New York, NY 10027 USA; 3.Columbia Univ, Dept Syst Biol, Ctr Computat Biol & Bioinformat C2B2, New York, NY 10027 USA; 4.New York Genome Ctr, New York, NY 10013 USA; 5.Hebrew Univ Jerusalem, Braun Sch Publ Hlth & Community Med, Jerusalem, Israel |
推荐引用方式 GB/T 7714 | Erlich, Yaniv,39;er, Itsik. Identity inference of genomic data using long-range familial searches[J]. SCIENCE,2018,362(6415):690-+. |
APA | Erlich, Yaniv,&39;er, Itsik.(2018).Identity inference of genomic data using long-range familial searches.SCIENCE,362(6415),690-+. |
MLA | Erlich, Yaniv,et al."Identity inference of genomic data using long-range familial searches".SCIENCE 362.6415(2018):690-+. |
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