Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles

doi:10.1126/science.aao0666

GSTDTAP > 地球科学

DOI	10.1126/science.aao0666
	Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles
	Choi, Hae Woong 1; Suwanpradid, Jutamas 2; Kim, Il Hwan 3; Staats, Herman F.1,4,5; Haniffa, Muzlifah 6,7; MacLeod, Amanda S.2,4; Abraham, Soman N.1,4,8,9
	2018-11-09
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2018
卷号	362 期号:6415 页码:656-+
文章类型	Article
语种	英语
国家	USA; England; Singapore
英文摘要	Anaphylactic reactions are triggered when allergens enter the blood circulation and activate immunoglobulin E (IgE)-sensitized mast cells (MCs), causing systemic discharge of prestored proinflammatory mediators. As MCs are extravascular, how they perceive circulating allergens remains a conundrum. Here, we describe the existence of a CD301b(+) perivascular dendritic cell (DC) subset that continuously samples blood and relays antigens to neighboring MCs, which vigorously degranulate and trigger anaphylaxis. DC antigen transfer involves the active discharge of surface-associated antigens on 0.5- to 1.0-micrometer microvesicles (MVs) generated by vacuolar protein sorting 4 (VPS4). Antigen sharing by DCs is not limited toMCs, as neighboring DCs also acquire antigen-bearing MVs. This capacity of DCs to distribute antigen-bearing MVs to various immune cells in the perivascular space potentiates inflammatory and immune responses to blood-borne antigens.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000450474500032
WOS关键词	IN-VIVO DEPLETION ; ANTIGEN ; MACROPHAGES ; PROGENITORS ; EXPRESSION ; MANAGEMENT ; ORIGINS ; SUBSET ; ZBTB46
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/200040
专题	地球科学资源环境科学气候变化
作者单位	1.Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA; 2.Duke Univ, Med Ctr, Dept Dermatol, Durham, NC 27710 USA; 3.Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA; 4.Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA; 5.Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27710 USA; 6.Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England; 7.Newcastle Upon Tyne NHS Trust, Dept Dermatol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England; 8.Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA; 9.Duke Natl Univ Singapore, Program Emerging Infect Dis, Singapore 169857, Singapore
推荐引用方式 GB/T 7714	Choi, Hae Woong,Suwanpradid, Jutamas,Kim, Il Hwan,et al. Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles[J]. SCIENCE,2018,362(6415):656-+.
APA	Choi, Hae Woong.,Suwanpradid, Jutamas.,Kim, Il Hwan.,Staats, Herman F..,Haniffa, Muzlifah.,...&Abraham, Soman N..(2018).Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles.SCIENCE,362(6415),656-+.
MLA	Choi, Hae Woong,et al."Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles".SCIENCE 362.6415(2018):656-+.