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DOI | 10.1126/science.aat9528 |
SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism | |
Kory, Nora1,2,3,4; Wyant, Gregory A.1,2,3,4; Prakash, Gyan1; de Bos, Jelmi Uit1; Bottanelli, Francesca5,7; Pacold, Michael E.1,2,3,4,6,8; Chan, Sze Ham1; Lewis, Caroline A.1; Wang, Tim1,2,3,4; Keys, Heather R.1; Guo, Yang Eric1; Sabatini, David M.1,2,3,4 | |
2018-11-16 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6416页码:791-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Germany |
英文摘要 | One-carbon metabolism generates the one-carbon units required to synthesize many critical metabolites, including nucleotides. The pathway has cytosolic and mitochondrial branches, and a key step is the entry, through an unknown mechanism, of serine into mitochondria, where it is converted into glycine and formate. In a CRISPR-based genetic screen in human cells for genes of the mitochondrial pathway, we found sideroflexin 1 (SFXN1), a multipass inner mitochondrial membrane protein of unclear function. Like cells missing mitochondrial components of one-carbon metabolism, those null for SFXN1 are defective in glycine and purine synthesis. Cells lacking SFXN1 and one of its four homologs, SFXN3, have more severe defects, including being auxotrophic for glycine. Purified SFXN1 transports serine in vitro. Thus, SFXN1 functions as a mitochondrial serine transporter in one-carbon metabolism. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000450488500042 |
WOS关键词 | GLYCINE ; PROTEIN ; IDENTIFICATION ; CARRIER ; ANEMIA ; PROLIFERATION ; LOCALIZATION ; INITIATION ; REVEALS ; SLC38A9 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200083 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Whitehead Inst Biomed Res, 455 Main St, Cambridge, MA 02142 USA; 2.MIT, Howard Hughes Med Inst, Dept Biol, Cambridge, MA 02139 USA; 3.MIT, Koch Inst Integrat Canc Res, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA; 4.Broad Inst Harvard & MIT, 415 Main St, Cambridge, MA 02142 USA; 5.Yale Univ, Dept Cell Biol, Sch Med, New Haven, CT 06520 USA; 6.NYU, Dept Radiat Oncol, Langone Med Ctr, New York, NY 10016 USA; 7.Free Univ Berlin, Fac Biol Chem & Pharm, D-14195 Berlin, Germany; 8.NYU, Langone Med Ctr, 522 First Ave,Smilow 907, New York, NY 10016 USA |
推荐引用方式 GB/T 7714 | Kory, Nora,Wyant, Gregory A.,Prakash, Gyan,et al. SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism[J]. SCIENCE,2018,362(6416):791-+. |
APA | Kory, Nora.,Wyant, Gregory A..,Prakash, Gyan.,de Bos, Jelmi Uit.,Bottanelli, Francesca.,...&Sabatini, David M..(2018).SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism.SCIENCE,362(6416),791-+. |
MLA | Kory, Nora,et al."SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism".SCIENCE 362.6416(2018):791-+. |
条目包含的文件 | 条目无相关文件。 |
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