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DOI | 10.1126/science.aat6141 |
Reversible self-assembly of superstructured networks | |
Freeman, Ronit1,9; Han, Ming2; Alvarez, Zaida1; Lewis, Jacob A.3; Wester, James R.1; Stephanopoulos, Nicholas1,10; McClendon, Mark T.1; Lynsky, Cheyenne1; Godbe, Jacqueline M.4; Sangji, Hussain3; Luijten, Erik5,6,7; Stupp, Samuel I.1,3,4,5,8 | |
2018-11-16 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6416页码:808-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Soft structures in nature, such as protein assemblies, can organize reversibly into functional and often hierarchical architectures through noncovalent interactions. Molecularly encoding this dynamic capability in synthetic materials has remained an elusive goal. We report on hydrogels of peptide-DNA conjugates and peptides that organize into superstructures of intertwined filaments that disassemble upon the addition of molecules or changes in charge density. Experiments and simulations demonstrate that this response requires large-scale spatial redistribution of molecules directed by strong noncovalent interactions among them. Simulations also suggest that the chemically reversible structures can only occur within a limited range of supramolecular cohesive energies. Storage moduli of the hydrogels change reversibly as superstructures form and disappear, as does the phenotype of neural cells in contact with these materials. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000450488500048 |
WOS关键词 | EXTRACELLULAR-MATRIX ; REACTIVE ASTROCYTES ; FORCE-FIELD ; PEPTIDE ; MOLECULES ; CULTURES ; PATHWAY ; FIBERS ; MODEL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200087 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Northwestern Univ, Simpson Querrey Inst, Chicago, IL 60611 USA; 2.Northwestern Univ, Appl Phys Grad Program, Evanston, IL 60208 USA; 3.Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA; 4.Northwestern Univ, Dept Chem, Evanston, IL 60208 USA; 5.Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA; 6.Northwestern Univ, Dept Engn Sci & Appl Math, Evanston, IL 60208 USA; 7.Northwestern Univ, Dept Phys & Astron, Evanston, IL 60208 USA; 8.Northwestern Univ, Dept Med, Chicago, IL 60611 USA; 9.Univ N Carolina, Dept Appl Phys Sci, Chapel Hill, NC 27599 USA; 10.Arizona State Univ, Sch Mol Sci, Biodesign Ctr Mol Design & Biomimet, Tempe, AZ 85287 USA |
推荐引用方式 GB/T 7714 | Freeman, Ronit,Han, Ming,Alvarez, Zaida,et al. Reversible self-assembly of superstructured networks[J]. SCIENCE,2018,362(6416):808-+. |
APA | Freeman, Ronit.,Han, Ming.,Alvarez, Zaida.,Lewis, Jacob A..,Wester, James R..,...&Stupp, Samuel I..(2018).Reversible self-assembly of superstructured networks.SCIENCE,362(6416),808-+. |
MLA | Freeman, Ronit,et al."Reversible self-assembly of superstructured networks".SCIENCE 362.6416(2018):808-+. |
条目包含的文件 | 条目无相关文件。 |
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