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DOI | 10.1126/science.aat8642 |
Molecular to organismal chirality is induced by the conserved myosin 1D | |
Lebreton, G.1,4; Geminard, C.1,5; Lapraz, F.1; Pyrpassopoulos, S.2,3; Cerezo, D.1; Speder, P.1,6; Ostap, E. M.2,3; Noselli, S.1 | |
2018-11-23 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6417页码:949-+ |
文章类型 | Article |
语种 | 英语 |
国家 | France; USA |
英文摘要 | The emergence of asymmetry from an initially symmetrical state is a universal transition in nature. Living organisms show asymmetries at the molecular, cellular, tissular, and organismal level. However, whether and how multilevel asymmetries are related remains unclear. In this study, we show that Drosophila myosin 1D (Myo1D) and myosin 1C (Myo1C) are sufficient to generate de novo directional twisting of cells, single organs, or the whole body in opposite directions. Directionality lies in the myosins' motor domain and is swappable between Myo1D and Myo1C. In addition, Myo1D drives gliding of actin filaments in circular, counterclockwise paths in vitro. Altogether, our results reveal the molecularmotor Myo1D as a chiral determinant that is sufficient to break symmetry at all biological scales through chiral interaction with the actin cytoskeleton. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000451124500043 |
WOS关键词 | LEFT-RIGHT ASYMMETRY ; UNCONVENTIONAL MYOSIN ; EXPRESSION ; HANDEDNESS ; ACTIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200136 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Cote DAzur, CNRS, INSERM, Inst Biol Valrose, Nice, France; 2.Univ Penn, Perelman Sch Med, Penn Muscle Inst, Philadelphia, PA 19104 USA; 3.Univ Penn, Perelman Sch Med, Ctr Engn Mech, Philadelphia, PA 19104 USA; 4.Univ Paul Sabatier, Ctr Biol Integrat, 118 Route Narbonne, F-31062 Toulouse, France; 5.INSERM, U1194, IRCM, 208 Ave Apothicaires, F-34298 Montpellier 5, France; 6.Inst Pasteur, 25 Rue Dr Roux, F-75015 Paris, France |
推荐引用方式 GB/T 7714 | Lebreton, G.,Geminard, C.,Lapraz, F.,et al. Molecular to organismal chirality is induced by the conserved myosin 1D[J]. SCIENCE,2018,362(6417):949-+. |
APA | Lebreton, G..,Geminard, C..,Lapraz, F..,Pyrpassopoulos, S..,Cerezo, D..,...&Noselli, S..(2018).Molecular to organismal chirality is induced by the conserved myosin 1D.SCIENCE,362(6417),949-+. |
MLA | Lebreton, G.,et al."Molecular to organismal chirality is induced by the conserved myosin 1D".SCIENCE 362.6417(2018):949-+. |
条目包含的文件 | 条目无相关文件。 |
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