Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aat1045 |
Maternal Huluwa dictates the embryonic body axis through beta-catenin in vertebrates | |
Yan, Lu1; Chen, Jing1; Zhu, Xuechen2; Sun, Jiawei1; Wu, Xiaotong1; Shen, Weimin1; Zhang, Weiying1; Tao, Qinghua2; Meng, Anming1 | |
2018-11-23 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6417页码:910-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | The vertebrate body is formed by cell movements and shape change during embryogenesis. It remains undetermined which maternal signals govern the formation of the dorsal organizer and the body axis. We found that maternal depletion of huluwa, a previously unnamed gene, causes loss of the dorsal organizer, the head, and the body axis in zebrafish and Xenopus embryos. Huluwa protein is found on the plasma membrane of blastomeres in the future dorsal region in early zebrafish blastulas. Huluwa has strong dorsalizing and secondary axis-inducing activities, which require beta-catenin but can function independent of Wnt ligand/receptor signaling. Mechanistically, Huluwa binds to and promotes the tankyrase-mediated degradation of Axin. Therefore, maternal Huluwa is an essential determinant of the dorsal organizer and body axis in vertebrate embryos. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000451124500033 |
WOS关键词 | WNT SIGNALING PATHWAY ; XENOPUS EMBRYOS ; ORGANIZER ; ROLES ; INHIBITION ; INDUCTION ; MESODERM ; PATTERN ; IDENTIFICATION ; ESTABLISHMENT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200141 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Tsinghua Univ, Lab Mol Dev Biol, State Key Lab Membrane Biol, Tsinghua Peking Ctr Life Sci,Sch Life Sci, Beijing 100084, Peoples R China; 2.Tsinghua Univ, Sch Life Sci, MOE Key Lab Prot Sci, Beijing 100084, Peoples R China |
推荐引用方式 GB/T 7714 | Yan, Lu,Chen, Jing,Zhu, Xuechen,et al. Maternal Huluwa dictates the embryonic body axis through beta-catenin in vertebrates[J]. SCIENCE,2018,362(6417):910-+. |
APA | Yan, Lu.,Chen, Jing.,Zhu, Xuechen.,Sun, Jiawei.,Wu, Xiaotong.,...&Meng, Anming.(2018).Maternal Huluwa dictates the embryonic body axis through beta-catenin in vertebrates.SCIENCE,362(6417),910-+. |
MLA | Yan, Lu,et al."Maternal Huluwa dictates the embryonic body axis through beta-catenin in vertebrates".SCIENCE 362.6417(2018):910-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论