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DOI | 10.1126/science.aar7607 |
ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation | |
Ruhl, Sebastian1,2; Shkarina, Kateryna3; Demarco, Benjamin3; Heilig, Rosalie3; Santos, Jose Carlos3; Broz, Petr1,3 | |
2018-11-23 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6417页码:956-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland; USA |
英文摘要 | Pyroptosis is a lytic form of cell death that is induced by inflammatory caspases upon activation of the canonical or noncanonical inflammasome pathways. These caspases cleave gasdermin D (GSDMD) to generate an N-terminal GSDMD fragment, which executes pyroptosis by forming membrane pores. We found that calcium influx through GSDMD pores serves as a signal for cells to initiate membrane repair by recruiting the endosomal sorting complexes required for transport (ESCRT) machinery to damaged membrane areas, such as the plasma membrane. Inhibition of the ESCRT-III machinery strongly enhances pyroptosis and interleukin-1 beta release in both human and murine cells after canonical or noncanonical inflammasome activation. These results not only attribute an anti-inflammatory role to membrane repair by the ESCRT-III system but also provide insight into general cellular survival mechanisms during pyroptosis. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000451124500045 |
WOS关键词 | GASDERMIN-D ; INFLAMMATORY CASPASES ; MECHANISM ; SECRETION ; ACTS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200143 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Basel, Biozentrum, Focal Area Infect Biol, Klingelbergstr 50-70, CH-4056 Basel, Switzerland; 2.St Jude Childrens Res Hosp, Dept Immunol, 332 N Lauderdale St, Memphis, TN 38105 USA; 3.Univ Lausanne, Dept Biochem, Chemin Boveresses 155, CH-1066 Epalinges, Switzerland |
推荐引用方式 GB/T 7714 | Ruhl, Sebastian,Shkarina, Kateryna,Demarco, Benjamin,et al. ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation[J]. SCIENCE,2018,362(6417):956-+. |
APA | Ruhl, Sebastian,Shkarina, Kateryna,Demarco, Benjamin,Heilig, Rosalie,Santos, Jose Carlos,&Broz, Petr.(2018).ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation.SCIENCE,362(6417),956-+. |
MLA | Ruhl, Sebastian,et al."ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation".SCIENCE 362.6417(2018):956-+. |
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