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DOI | 10.1126/science.aat7148 |
Salmonella persisters undermine host immune defenses during antibiotic treatment | |
Stapels, Daphne A. C.1,4; Hill, Peter W. S.1; Westermann, Alexander J.2,3; Fisher, Robert A.1; Thurston, Teresa L.1; Saliba, Antoine-Emmanuel3; Blommestein, Isabelle1; Vogel, Joerg2,3; Helaine, Sophie1 | |
2018-12-07 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6419页码:1156-+ |
文章类型 | Article |
语种 | 英语 |
国家 | England; Germany; Netherlands |
英文摘要 | Many bacterial infections are hard to treat and tend to relapse, possibly due to the presence of antibiotic-tolerant persisters. In vitro, persister cells appear to be dormant. After uptake of Salmonella species by macrophages, nongrowing persisters also occur, but their physiological state is poorly understood. In this work, we show that Salmonella persisters arising during macrophage infection maintain a metabolically active state. Persisters reprogram macrophages by means of effectors secreted by the Salmonella pathogenicity island 2 type 3 secretion system. These effectors dampened proinflarnmatory innate immune responses and induced anti-inflammatory macrophage polarization. Such reprogramming allowed nongrowing Salmonella cells to survive for extended periods in their host. Persisters undermining host immune defenses might confer an advantage to the pathogen during relapse once antibiotic pressure is relieved. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000452506300057 |
WOS关键词 | HEMOPHAGOCYTIC MACROPHAGES ; MOLECULAR-MECHANISMS ; ACTIVATION ; INFECTION ; REPLICATION ; ENTERICA ; FEVER |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200244 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Imperial Coll London, Ctr Mol Bacteriol & Infect, MRC, London, England; 2.Univ Wurzburg, Inst Mol Infect Biol, Wurzburg, Germany; 3.Helmholtz Inst RNA Based Infect Res, Wurzburg, Germany; 4.Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands |
推荐引用方式 GB/T 7714 | Stapels, Daphne A. C.,Hill, Peter W. S.,Westermann, Alexander J.,et al. Salmonella persisters undermine host immune defenses during antibiotic treatment[J]. SCIENCE,2018,362(6419):1156-+. |
APA | Stapels, Daphne A. C..,Hill, Peter W. S..,Westermann, Alexander J..,Fisher, Robert A..,Thurston, Teresa L..,...&Helaine, Sophie.(2018).Salmonella persisters undermine host immune defenses during antibiotic treatment.SCIENCE,362(6419),1156-+. |
MLA | Stapels, Daphne A. C.,et al."Salmonella persisters undermine host immune defenses during antibiotic treatment".SCIENCE 362.6419(2018):1156-+. |
条目包含的文件 | 条目无相关文件。 |
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