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DOI | 10.1126/science.aar3932 |
An evolutionary perspective on immunometabolism | |
Wang, Andrew1; Luan, Harding H.2; Medzhitov, Ruslan2,3 | |
2019-01-11 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6423页码:140-140 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Metabolism is at the core of all biological functions. Anabolic metabolism uses building blocks that are either derived from nutrients or synthesized de novo to produce the biological infrastructure, whereas catabolic metabolism generates energy to fuel all biological processes. Distinct metabolic programs are required to support different biological functions. Thus, recent studies have revealed how signals regulating cell quiescence, proliferation, and differentiation also induce the appropriate metabolic programs. In particular, a wealth of new studies in the field of immunometabolism has unveiled many examples of the connection among metabolism, cell fate decisions, and organismal physiology. We discuss these findings under a unifying framework derived from the evolutionary and ecological principles of life history theory. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000455320600037 |
WOS关键词 | NECROSIS-FACTOR-ALPHA ; BETA-HYDROXYBUTYRATE ; OXIDATIVE STRESS ; MACROPHAGE METABOLISM ; SICKNESS BEHAVIOR ; CELL-ACTIVATION ; MOLECULAR-BASIS ; DENDRITIC CELL ; GROWTH-HORMONE ; NITRIC-OXIDE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200514 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Yale Univ, Sch Med, Dept Med Rheumatol, New Haven, CT 06520 USA; 2.Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA; 3.Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA |
推荐引用方式 GB/T 7714 | Wang, Andrew,Luan, Harding H.,Medzhitov, Ruslan. An evolutionary perspective on immunometabolism[J]. SCIENCE,2019,363(6423):140-140. |
APA | Wang, Andrew,Luan, Harding H.,&Medzhitov, Ruslan.(2019).An evolutionary perspective on immunometabolism.SCIENCE,363(6423),140-140. |
MLA | Wang, Andrew,et al."An evolutionary perspective on immunometabolism".SCIENCE 363.6423(2019):140-140. |
条目包含的文件 | 条目无相关文件。 |
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