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DOI | 10.1126/science.aat1650 |
A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila | |
Toda, Hirofumi1; Williams, Julie A.1; Gulledge, Michael1,2,3; Sehgal, Amita1 | |
2019-02-01 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6426页码:509-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Sleep remains a major mystery of biology. In particular, little is known about the mechanisms that account for the drive to sleep. In an unbiased screen of more than 12,000 Drosophila lines, we identified a single gene, nemuri, that induces sleep. The NEMURI protein is an antimicrobial peptide that can be secreted ectopically to drive prolonged sleep (with resistance to arousal) and to promote survival after infection. Loss of nemuri increased arousability during daily sleep and attenuated the acute increase in sleep induced by sleep deprivation or bacterial infection. Conditions that increase sleep drive induced expression of nemuri in a small number of fly brain neurons and targeted it to the sleep-promoting, dorsal fan-shaped body. We propose that NEMURI is a bona fide sleep homeostasis factor that is particularly important under conditions of high sleep need; because these conditions include sickness, our findings provide a link between sleep and immune function. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000457409400045 |
WOS关键词 | ANTIMICROBIAL PEPTIDES ; BACTERIAL-INFECTION ; PROMOTES SURVIVAL ; CYCLIN-A ; AROUSAL ; STRESS ; INTERLEUKIN-1-ALPHA ; IDENTIFICATION ; ORGANIZATION ; DEPRIVATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200669 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Penn, Howard Hughes Med Inst, Chronobiol Program, Perelman Sch Med, Philadelphia, PA 19104 USA; 2.Harvard Univ, Program Neurosci, Belmont, MA 02478 USA; 3.McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA |
推荐引用方式 GB/T 7714 | Toda, Hirofumi,Williams, Julie A.,Gulledge, Michael,et al. A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila[J]. SCIENCE,2019,363(6426):509-+. |
APA | Toda, Hirofumi,Williams, Julie A.,Gulledge, Michael,&Sehgal, Amita.(2019).A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila.SCIENCE,363(6426),509-+. |
MLA | Toda, Hirofumi,et al."A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila".SCIENCE 363.6426(2019):509-+. |
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