Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aav9370 |
How a circularized tmRNA moves through the ribosome | |
Rae, Christopher D.; Gordiyenko, Yuliya; Ramakrishnan, V. | |
2019-02-15 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6428页码:740-+ |
文章类型 | Article |
语种 | 英语 |
国家 | England |
英文摘要 | During trans-translation, transfer-messenger RNA (tmRNA) and small protein B (SmpB) together rescue ribosomes stalled on a truncated mRNA and tag the nascent polypeptide for degradation. We used cryo-electron microscopy to determine the structures of three key states of the tmRNA-SmpB-ribosome complex during trans translation at resolutions of 3.7 to 4.4 angstroms. The results show how tmRNA and SmpB act specifically on stalled ribosomes and how the circularized complexmoves through the ribosome, enabling translation to switch from the old defective message to the reading frame on tmRNA. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000458874100033 |
WOS关键词 | SMALL PROTEIN-B ; MESSENGER-RNA ; TRANS-TRANSLATION ; TAGGING ACTIVITY ; STRUCTURAL BASIS ; 10SA RNA ; SMPB ; RESCUE ; SYSTEM ; ACTIVATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200759 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | MRC, Mol Biol Lab, Francis Crick Ave, Cambridge, England |
推荐引用方式 GB/T 7714 | Rae, Christopher D.,Gordiyenko, Yuliya,Ramakrishnan, V.. How a circularized tmRNA moves through the ribosome[J]. SCIENCE,2019,363(6428):740-+. |
APA | Rae, Christopher D.,Gordiyenko, Yuliya,&Ramakrishnan, V..(2019).How a circularized tmRNA moves through the ribosome.SCIENCE,363(6428),740-+. |
MLA | Rae, Christopher D.,et al."How a circularized tmRNA moves through the ribosome".SCIENCE 363.6428(2019):740-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论