Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aau8475 |
BCR-dependent lineage plasticity in mature B cells | |
Graf, Robin1; Seagal, Jane2,3,9; Section, Kevin L. Otipoby2,3,10; Lam, Kong-Peng4,11; Ayoub, Salah5; Zhang, Baochun2,3,6; Sander, Sandrine1,7; Van Trung Chu1,8; Rajewsky, Klaus1,2,3,4 | |
2019-02-15 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6428页码:748-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; USA; Singapore |
英文摘要 | B2 cells engage in classical antibody responses, whereas B1 cells are considered carriers of innate immunity, biased toward recognizing epitopes present on the surfaces of common pathogens and self antigens. To explore the role of B cell antigen receptor (BCR) specificity in driving B1 cell differentiation, we developed a transgenic system allowing us to change BCR specificity in B cells in an inducible and programmedmanner. Mature B2 cells differentiated into bona fide B1 cells upon acquisition of a B1 cell-typical self-reactive BCR through a phase of proliferative expansion. Thus, B2 cells have B1 cell differentiation potential in addition to their classical capacity to differentiate into memory and plasma cells, and B1 differentiation can be instructed by BCR-mediated self-reactivity, in the absence of B1-lineage precommitment. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000458874100035 |
WOS关键词 | ANTIGEN RECEPTOR SPECIFICITY ; LY-1 B ; PHOSPHATIDYL CHOLINE ; MARGINAL ZONE ; B-1 CELLS ; VH GENE ; GENERATION ; REARRANGEMENT ; REPERTOIRE ; EXPRESSION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200771 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Helmholtz Assoc, Max Delbruck Ctr Mol Med, Immune Regulat & Canc, D-13125 Berlin, Germany; 2.Childrens Hosp, Program Cellular & Mol Med, 300 Longwood Ave, Boston, MA 02115 USA; 3.Harvard Med Sch, Immune Dis Inst, Boston, MA 02115 USA; 4.Univ Cologne, Inst Genet, D-50674 Cologne, Germany; 5.Helmholtz Assoc, Max Delbruck Ctr Mol Med, Syst Biol Gene Regulatory Elements, D-13125 Berlin, Germany; 6.Harvard Med Sch, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA; 7.German Canc Res Ctr, Natl Ctr Tumor Dis Heidelberg, Adapt Immun & Lymphoma, D-69120 Heidelberg, Germany; 8.Berlin Inst Hlth, D-10117 Berlin, Germany; 9.AbbVie Biores Ctr, Worcester, MA 01605 USA; 10.Pandion Therapeut, Cambridge, MA 02139 USA; 11.Agcy Sci Technol & Res, Bioproc Technol Inst, Immunol Grp, Singapore 138673, Singapore |
推荐引用方式 GB/T 7714 | Graf, Robin,Seagal, Jane,Section, Kevin L. Otipoby,et al. BCR-dependent lineage plasticity in mature B cells[J]. SCIENCE,2019,363(6428):748-+. |
APA | Graf, Robin.,Seagal, Jane.,Section, Kevin L. Otipoby.,Lam, Kong-Peng.,Ayoub, Salah.,...&Rajewsky, Klaus.(2019).BCR-dependent lineage plasticity in mature B cells.SCIENCE,363(6428),748-+. |
MLA | Graf, Robin,et al."BCR-dependent lineage plasticity in mature B cells".SCIENCE 363.6428(2019):748-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论