Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

doi:10.1126/science.aau0964

GSTDTAP > 地球科学

DOI	10.1126/science.aau0964
	Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches
	Chakarov, Svetoslav 1; Lim, Hwee Ying 2; Tan, Leonard 1; Lim, Sheau Yng 2; See, Peter 1; Lum, Josephine 1; Zhang, Xiao-Meng 1; Foo, Shihui 1; Nakamizo, Satoshi 1; Duan, Kaibo 1; Kong, Wan Ting 1; Gentek, Rebecca 3; Balachander, Akhila 1; Carbajo, Daniel 1; Bleriot, Camille 1; Malleret, Benoit 1,2; Tam, John Kit Chung 4; Baig, Sonia 5; Shabeer, Muhammad 5; Toh, Sue-Anne Ee Shiow 5; Schlitzer, Andreas 6; Larbi, Anis 1; Marichal, Thomas 7,8,9; Malissen, Bernard 3,10; Chen, Jinmiao 1; Poidinger, Michael 1; Kabashima, Kenji 1,11; Bajenoff, Marc 3; Ng, Lai Guan 1; Angeli, Veronique 2; Ginhoux, Florent 1
	2019-03-15
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2019
卷号	363 期号:6432 页码:1190-+
文章类型	Article
语种	英语
国家	Singapore; France; Germany; Belgium; Japan
英文摘要	Macrophages are a heterogeneous cell population involved in tissue homeostasis, inflammation, and various pathologies. Although the major tissue-resident macrophage populations have been extensively studied, interstitial macrophages (IMs) residing within the tissue parenchyma remain poorly defined. Here we studied IMs from murine lung, fat, heart, and dermis. We identified two independent IM subpopulations that are conserved across tissues: Lyve1(lo)MHCII(hi)CX3CR1(hi) (Lyve1(lo)MHCII(hi)) and Lyve1(hi)MHCII(lo)CX3CR1(lo) (Lyve1(hi)MHCII(lo)) monocyte-derived IMs, with distinct gene expression profiles, phenotypes, functions, and localizations. Using a new mouse model of inducible macrophage depletion (Slco2b1(flox/DTR)), we found that the absence of Lyve1(hi)MHCII(lo) IMs exacerbated experimental lung fibrosis. Thus, we demonstrate that two independent populations of IMs coexist across tissues and exhibit conserved niche-dependent functional programming.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000461329000040
WOS关键词	RESIDENT CARDIAC MACROPHAGES ; INDUCED PULMONARY-FIBROSIS ; DENDRITIC CELLS ; FETAL MONOCYTES ; LYVE-1-POSITIVE MACROPHAGES ; EXPRESSION ; IDENTIFICATION ; RECEPTOR ; REVEALS ; FATE
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/200973
专题	地球科学资源环境科学气候变化
作者单位	1.ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3, Singapore 138648, Singapore; 2.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol & Immunol, Singapore 119228, Singapore; 3.Aix Marseille Univ, Ctr Immunol Marseille Luminy, INSERM, CNRS, F-13288 Marseille, France; 4.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, 1E Kent Ridge Rd, Singapore 119228, Singapore; 5.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 119228, Singapore; 6.Univ Bonn, Myeloid Cell Biol Life & Med Sci Inst, D-53115 Bonn, Germany; 7.Univ Liege, Lab Cellular & Mol Immunol, GIGA Res, B-4000 Liege, Belgium; 8.Univ Liege, Fac Vet Med, B-4000 Liege, Belgium; 9.Walloon Excellence Life Sci & Biotechnol, WELBIO, B-1300 Wallonia, Belgium; 10.Aix Marseille Univ, Ctr Immunophenom, INSERM, CNRS UMR, F-13288 Marseille, France; 11.Kyoto Univ, Grad Sch Med, Dept Dermatol, Kyoto 6068507, Japan
推荐引用方式 GB/T 7714	Chakarov, Svetoslav,Lim, Hwee Ying,Tan, Leonard,et al. Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches[J]. SCIENCE,2019,363(6432):1190-+.
APA	Chakarov, Svetoslav.,Lim, Hwee Ying.,Tan, Leonard.,Lim, Sheau Yng.,See, Peter.,...&Ginhoux, Florent.(2019).Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches.SCIENCE,363(6432),1190-+.
MLA	Chakarov, Svetoslav,et al."Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches".SCIENCE 363.6432(2019):1190-+.