Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aav9959 |
Developmental control of plant Rho GTPase nano-organization by the lipid phosphatidylserine | |
Platre, Matthieu Pierre1; Bayle, Vincent1; Armengot, Laia1; Bareille, Joseph1; Marques-Bueno, Maria del Mar1; Creff, Audrey1; Maneta-Peyret, Lilly2; Fiche, Jean-Bernard3; Nollmann, Marcelo3; Miege, Christine1; Moreau, Patrick2,4; Martiniere, Alexandre5; Jaillais, Yvon1 | |
2019-04-05 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6435页码:57-+ |
文章类型 | Article |
语种 | 英语 |
国家 | France |
英文摘要 | Rho guanosine triphosphatases (GTPases) are master regulators of cell signaling, but how they are regulated depending on the cellular context is unclear. We found that the phospholipid phosphatidylserine acts as a developmentally controlled lipid rheostat that tunes Rho GTPase signaling in Arabidopsis. Live superresolution single-molecule imaging revealed that the protein Rho of Plants 6 (ROP6) is stabilized by phosphatidylserine into plasma membrane nanodomains, which are required for auxin signaling. Our experiments also revealed that the plasma membrane phosphatidylserine content varies during plant root development and that the level of phosphatidylserine modulates the quantity of ROP6 nanoclusters induced by auxin and hence downstream signaling, including regulation of endocytosis and gravitropism. Our work shows that variations in phosphatidylserine levels are a physiological process that may be leveraged to regulate small GTPase signaling during development. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000463585700032 |
WOS关键词 | RECEPTOR ACTIVATION ; CELL-SURFACE ; K-RAS ; MEMBRANE ; AUXIN ; PROTEINS ; IMAGE ; PI(4,5)P-2 ; TRANSPORT ; DYNAMICS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201126 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Lyon, UCB Lyon 1, Lab Reprod & Dev Plantes, ENS Lyon,CNRS,INRA, F-69342 Lyon, France; 2.CNRS Univ Bordeaux, INRA Bordeaux Aquitaine, UMR Membrane Biogenesis Lab 5200, F-33140 Villenave Dornon, France; 3.Univ Montpellier, Ctr Biochim Struct, CNRS UMR5048, INSERM U1054, F-34090 Montpellier, France; 4.Univ Bordeaux, Bordeaux Imaging Ctr, UMS CNRS 3420, INSERM US4, F-33000 Bordeaux, France; 5.Univ Montpellier, BPMP, CNRS, INRA,Montpellier SupAgro, Montpellier, France |
推荐引用方式 GB/T 7714 | Platre, Matthieu Pierre,Bayle, Vincent,Armengot, Laia,et al. Developmental control of plant Rho GTPase nano-organization by the lipid phosphatidylserine[J]. SCIENCE,2019,364(6435):57-+. |
APA | Platre, Matthieu Pierre.,Bayle, Vincent.,Armengot, Laia.,Bareille, Joseph.,Marques-Bueno, Maria del Mar.,...&Jaillais, Yvon.(2019).Developmental control of plant Rho GTPase nano-organization by the lipid phosphatidylserine.SCIENCE,364(6435),57-+. |
MLA | Platre, Matthieu Pierre,et al."Developmental control of plant Rho GTPase nano-organization by the lipid phosphatidylserine".SCIENCE 364.6435(2019):57-+. |
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