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DOI | 10.1126/science.aav9856 |
Small peptide-mediated self-recognition prevents cannibalism in predatory nematodes | |
Lightfoot, James W.1; Wilecki, Martin1; Roedelsperger, Christian1; Moreno, Eduardo1; Susoy, Vladislav2; Witte, Hanh1; Sommer, Ralf J.1 | |
2019-04-05 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6435页码:86-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; USA |
英文摘要 | Self-recognition is observed abundantly throughout the natural world, regulating diverse biological processes. Although ubiquitous, often little is known of the associated molecular machinery, and so far, organismal self-recognition has never been described in nematodes. We investigated the predatory nematode Pristionchus pacificus and, through interactions with its prey, revealed a self-recognition mechanism acting on the nematode surface, capable of distinguishing self-progeny from closely related strains. We identified the small peptide SELF-1, which is composed of an invariant domain and a hypervariable C terminus, as a key component of self-recognition. Modifications to the hypervariable region, including single-amino acid substitutions, are sufficient to eliminate self-recognition. Thus, the P. pacificus self-recognition system enables this nematode to avoid cannibalism while promoting the killing of competing nematodes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000463585700039 |
WOS关键词 | PRISTIONCHUS-PACIFICUS ; FEEDING-BEHAVIOR ; GENE ; PLASTICITY ; DIVERSITY ; REVEALS ; SYSTEM ; RNA |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201127 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Max Planck Inst Dev Biol, Max Planck Ring 9, D-72076 Tubingen, Germany; 2.Harvard Univ, Dept Phys, 52 Oxford St, Cambridge, MA 02138 USA |
推荐引用方式 GB/T 7714 | Lightfoot, James W.,Wilecki, Martin,Roedelsperger, Christian,et al. Small peptide-mediated self-recognition prevents cannibalism in predatory nematodes[J]. SCIENCE,2019,364(6435):86-+. |
APA | Lightfoot, James W..,Wilecki, Martin.,Roedelsperger, Christian.,Moreno, Eduardo.,Susoy, Vladislav.,...&Sommer, Ralf J..(2019).Small peptide-mediated self-recognition prevents cannibalism in predatory nematodes.SCIENCE,364(6435),86-+. |
MLA | Lightfoot, James W.,et al."Small peptide-mediated self-recognition prevents cannibalism in predatory nematodes".SCIENCE 364.6435(2019):86-+. |
条目包含的文件 | 条目无相关文件。 |
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