GSTDTAP  > 地球科学
DOI10.1126/science.aav9856
Small peptide-mediated self-recognition prevents cannibalism in predatory nematodes
Lightfoot, James W.1; Wilecki, Martin1; Roedelsperger, Christian1; Moreno, Eduardo1; Susoy, Vladislav2; Witte, Hanh1; Sommer, Ralf J.1
2019-04-05
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2019
卷号364期号:6435页码:86-+
文章类型Article
语种英语
国家Germany; USA
英文摘要

Self-recognition is observed abundantly throughout the natural world, regulating diverse biological processes. Although ubiquitous, often little is known of the associated molecular machinery, and so far, organismal self-recognition has never been described in nematodes. We investigated the predatory nematode Pristionchus pacificus and, through interactions with its prey, revealed a self-recognition mechanism acting on the nematode surface, capable of distinguishing self-progeny from closely related strains. We identified the small peptide SELF-1, which is composed of an invariant domain and a hypervariable C terminus, as a key component of self-recognition. Modifications to the hypervariable region, including single-amino acid substitutions, are sufficient to eliminate self-recognition. Thus, the P. pacificus self-recognition system enables this nematode to avoid cannibalism while promoting the killing of competing nematodes.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000463585700039
WOS关键词PRISTIONCHUS-PACIFICUS ; FEEDING-BEHAVIOR ; GENE ; PLASTICITY ; DIVERSITY ; REVEALS ; SYSTEM ; RNA
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/201127
专题地球科学
资源环境科学
气候变化
作者单位1.Max Planck Inst Dev Biol, Max Planck Ring 9, D-72076 Tubingen, Germany;
2.Harvard Univ, Dept Phys, 52 Oxford St, Cambridge, MA 02138 USA
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GB/T 7714
Lightfoot, James W.,Wilecki, Martin,Roedelsperger, Christian,et al. Small peptide-mediated self-recognition prevents cannibalism in predatory nematodes[J]. SCIENCE,2019,364(6435):86-+.
APA Lightfoot, James W..,Wilecki, Martin.,Roedelsperger, Christian.,Moreno, Eduardo.,Susoy, Vladislav.,...&Sommer, Ralf J..(2019).Small peptide-mediated self-recognition prevents cannibalism in predatory nematodes.SCIENCE,364(6435),86-+.
MLA Lightfoot, James W.,et al."Small peptide-mediated self-recognition prevents cannibalism in predatory nematodes".SCIENCE 364.6435(2019):86-+.
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