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DOI | 10.1126/science.aav0748 |
Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptides | |
Buscaill, Pierre1; Chandrasekar, Balakumaran1,4; Sanguankiattichai, Nattapong1; Kourelis, Jiorgos1; Kaschani, Farnusch2; Thomas, Emma L.1; Morimoto, Kyoko1; Kaiser, Markus2; Preston, Gail M.1; Ichinose, Yuki3; van der Hoorn, Renier A. L.1 | |
2019-04-12 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6436页码:145-+ |
文章类型 | Article |
语种 | 英语 |
国家 | England; Germany; Japan |
英文摘要 | Plants and animals recognize conserved flagellin fragments as a signature of bacterial invasion. These immunogenic elicitor peptides are embedded in the flagellin polymer and require hydrolytic release before they can activate cell surface receptors. Although much of flagellin signaling is understood, little is known about the release of immunogenic fragments. We discovered that plant-secreted beta-galactosidase 1 (BGAL1) of Nicotiana benthamiana promotes hydrolytic elicitor release and acts in immunity against pathogenic Pseudomonas syringae strains only when they carry a terminal modified viosamine (mVio) in the flagellin O-glycan. In counter defense, P. syringae pathovars evade host immunity by using BGAL1-resistant O-glycans or by producing a BGAL1 inhibitor. Polymorphic glycans on flagella are common to plant and animal pathogenic bacteria and represent an important determinant of host immunity to bacterial pathogens. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000464620000032 |
WOS关键词 | PV. SYRINGAE B728A ; PSEUDOMONAS-SYRINGAE ; NICOTIANA-BENTHAMIANA ; MOLECULAR-PATTERN ; RECEPTOR KINASE ; INNATE IMMUNITY ; IDENTIFICATION ; GLYCOSYLATION ; ARABIDOPSIS ; PERCEPTION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201196 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Oxford, Dept Plant Sci, Oxford, England; 2.Univ Duisburg Essen, ZMB Chem Biol, Fac Biol, Essen, Germany; 3.Okayama Univ, Grad Sch Environm & Life Sci, Okayama, Japan; 4.Heinrich Heine Univ, Inst Pflanzliche Zellbiol & Biotechnol, Dusseldorf, Germany |
推荐引用方式 GB/T 7714 | Buscaill, Pierre,Chandrasekar, Balakumaran,Sanguankiattichai, Nattapong,et al. Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptides[J]. SCIENCE,2019,364(6436):145-+. |
APA | Buscaill, Pierre.,Chandrasekar, Balakumaran.,Sanguankiattichai, Nattapong.,Kourelis, Jiorgos.,Kaschani, Farnusch.,...&van der Hoorn, Renier A. L..(2019).Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptides.SCIENCE,364(6436),145-+. |
MLA | Buscaill, Pierre,et al."Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptides".SCIENCE 364.6436(2019):145-+. |
条目包含的文件 | 条目无相关文件。 |
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