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DOI | 10.1126/science.aat8078 |
Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation | |
Moda-Sava, R. N.1,2; Murdock, M. H.1,2; Parekh, P. K.1,2; Fetcho, R. N.1,2; Huang, B. S.1,2; Huynh, T. N.1,2; Witztum, J.1,2; Shaver, D. C.1,2; Rosenthal, D. L.1,2; Alway, E. J.1,2; Lopez, K.1,2; Meng, Y.1,2; Nellissen, L.1,2; Grosenick, L.1,2,3,4; Milner, T. A.1,2; Deisseroth, K.3,4; Bito, H.5; Kasai, H.6,7; Liston, C.1,2 | |
2019-04-12 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 364期号:6436页码:147-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Japan |
英文摘要 | The neurobiological mechanisms underlying the induction and remission of depressive episodes over time are not well understood. Through repeated longitudinal imaging of medial prefrontal microcircuits in the living brain, we found that prefrontal spinogenesis plays a critical role in sustaining specific antidepressant behavioral effects and maintaining long-term behavioral remission. Depression-related behavior was associated with targeted, branch-specific elimination of postsynaptic dendritic spines on prefrontal projection neurons. Antidepressant-dose ketamine reversed these effects by selectively rescuing eliminated spines and restoring coordinated activity in multicellular ensembles that predict motivated escape behavior. Prefrontal spinogenesis was required for the long-term maintenance of antidepressant effects on motivated escape behavior but not for their initial induction. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000464620000034 |
WOS关键词 | DEPENDENT SYNAPSE FORMATION ; CHRONIC CORTICOSTERONE ; CHRONIC STRESS ; DENDRITIC MORPHOLOGY ; MEMORY PERFORMANCE ; LATERAL HABENULA ; SOCIAL DEFEAT ; PLASTICITY ; BRAIN ; MODEL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/201202 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Weill Cornell Med, Dept Psychiat, Brain & Mind Res Inst, New York, NY 10021 USA; 2.Weill Cornell Med, Sackler Inst Dev Psychobiol, New York, NY 10021 USA; 3.Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA; 4.Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA; 5.Univ Tokyo, Grad Sch Med, Dept Neurochem, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan; 6.Univ Tokyo, Ctr Dis Biol & Integrat Med, Lab Struct Physiol, Fac Med,Bunkyo Ku, Tokyo 1130033, Japan; 7.Univ Tokyo, UTIAS, Int Res Ctr Neurointelligence WPI IRCN, Bunkyo Ku, Tokyo 1130033, Japan |
推荐引用方式 GB/T 7714 | Moda-Sava, R. N.,Murdock, M. H.,Parekh, P. K.,et al. Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation[J]. SCIENCE,2019,364(6436):147-+. |
APA | Moda-Sava, R. N..,Murdock, M. H..,Parekh, P. K..,Fetcho, R. N..,Huang, B. S..,...&Liston, C..(2019).Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation.SCIENCE,364(6436),147-+. |
MLA | Moda-Sava, R. N.,et al."Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation".SCIENCE 364.6436(2019):147-+. |
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