GSTDTAP  > 地球科学
DOI10.1126/science.aat8078
Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation
Moda-Sava, R. N.1,2; Murdock, M. H.1,2; Parekh, P. K.1,2; Fetcho, R. N.1,2; Huang, B. S.1,2; Huynh, T. N.1,2; Witztum, J.1,2; Shaver, D. C.1,2; Rosenthal, D. L.1,2; Alway, E. J.1,2; Lopez, K.1,2; Meng, Y.1,2; Nellissen, L.1,2; Grosenick, L.1,2,3,4; Milner, T. A.1,2; Deisseroth, K.3,4; Bito, H.5; Kasai, H.6,7; Liston, C.1,2
2019-04-12
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2019
卷号364期号:6436页码:147-+
文章类型Article
语种英语
国家USA; Japan
英文摘要

The neurobiological mechanisms underlying the induction and remission of depressive episodes over time are not well understood. Through repeated longitudinal imaging of medial prefrontal microcircuits in the living brain, we found that prefrontal spinogenesis plays a critical role in sustaining specific antidepressant behavioral effects and maintaining long-term behavioral remission. Depression-related behavior was associated with targeted, branch-specific elimination of postsynaptic dendritic spines on prefrontal projection neurons. Antidepressant-dose ketamine reversed these effects by selectively rescuing eliminated spines and restoring coordinated activity in multicellular ensembles that predict motivated escape behavior. Prefrontal spinogenesis was required for the long-term maintenance of antidepressant effects on motivated escape behavior but not for their initial induction.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000464620000034
WOS关键词DEPENDENT SYNAPSE FORMATION ; CHRONIC CORTICOSTERONE ; CHRONIC STRESS ; DENDRITIC MORPHOLOGY ; MEMORY PERFORMANCE ; LATERAL HABENULA ; SOCIAL DEFEAT ; PLASTICITY ; BRAIN ; MODEL
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/201202
专题地球科学
资源环境科学
气候变化
作者单位1.Weill Cornell Med, Dept Psychiat, Brain & Mind Res Inst, New York, NY 10021 USA;
2.Weill Cornell Med, Sackler Inst Dev Psychobiol, New York, NY 10021 USA;
3.Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA;
4.Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA;
5.Univ Tokyo, Grad Sch Med, Dept Neurochem, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan;
6.Univ Tokyo, Ctr Dis Biol & Integrat Med, Lab Struct Physiol, Fac Med,Bunkyo Ku, Tokyo 1130033, Japan;
7.Univ Tokyo, UTIAS, Int Res Ctr Neurointelligence WPI IRCN, Bunkyo Ku, Tokyo 1130033, Japan
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GB/T 7714
Moda-Sava, R. N.,Murdock, M. H.,Parekh, P. K.,et al. Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation[J]. SCIENCE,2019,364(6436):147-+.
APA Moda-Sava, R. N..,Murdock, M. H..,Parekh, P. K..,Fetcho, R. N..,Huang, B. S..,...&Liston, C..(2019).Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation.SCIENCE,364(6436),147-+.
MLA Moda-Sava, R. N.,et al."Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation".SCIENCE 364.6436(2019):147-+.
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